Lifespan and reproduction in Drosophila: New insights from nutritional geometry
Kwang Pum Lee,Stephen J. Simpson,Fiona J. Clissold,Robert C. Brooks,J. William O. Ballard,Phil W. Taylor,Nazaneen Soran,David Raubenheimer +7 more
TLDR
The use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster indicates a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein.Abstract:
Modest dietary restriction (DR) prolongs life in a wide range of organisms, spanning single-celled yeast to mammals. Here, we report the use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster. Caloric restriction (CR) was not responsible for extending lifespan in our experimental flies. Response surfaces for lifespan and fecundity were maximized at different protein–carbohydrate intakes, with longevity highest at a protein-to-carbohydrate ratio of 1:16 and egg-laying rate maximized at 1:2. Lifetime egg production, the measure closest to fitness, was maximized at an intermediate P:C ratio of 1:4. Flies offered a choice of complementary foods regulated intake to maximize lifetime egg production. The results indicate a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein. We unite a body of apparently conflicting work within a common framework and provide a platform for studying aging in all organisms.read more
Citations
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Journal ArticleDOI
An Evolutionary Model of “Sexual Conflict” Over Women's Age at Marriage: Implications for Child Mortality and Undernutrition
TL;DR: In this article , a simple mathematical model was developed to explore women's optimal marriage age under different circumstances, if the sole aim were to maximize maternal or paternal lifetime reproductive fitness (surviving offspring).
Journal ArticleDOI
Dietary restriction fails to extend life in stressful environments
TL;DR: The authors found that protein restriction increased longevity of one or both sexes at benign ambient temperatures (25°C and 27°C), but failed to extend longevity of flies maintained in cold or hot conditions.
Posted ContentDOI
The effect of nutrient storage on courtship behavior and copulation frequency in the fruit fly, Drosophila melanogaster
TL;DR: In this article, the effects of diet and metabolic energy storage on reproductive behaviors of Drosophila melanogaster have been studied, showing that a high fat diet either increases male attractivity or male courtship persistence.
Dissertation
Exploring the effects of dietary restriction and macronutrient composition on life-history traits in a non-model vertebrate system
TL;DR: The aim of this work is to contribute to the understanding of nutrition and fitness in the context of vertebrate vertebrates and its role in the animal kingdom.
Journal ArticleDOI
Effects of cassava starch supplementation on behavioural characteristics and oxidative status in Drosophila melanogaster
Olarewaju M. Oluba,M. M. Ayodele,A. G. Adeyonu,A.J. Shoyombo,Olayinka O. Alabi,Oghenerobor B. Akpor +5 more
TL;DR: Data obtained from this study revealed that supplementation to the D. melanogaster diet with cassava starch enhances the organism's survival rate, and adaptive response to cold stress, with concomitant improvement in antioxidant status.
References
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Book
The Retardation of Aging and Disease by Dietary Restriction
Richard Weindruch,Roy L. Walford +1 more
Journal ArticleDOI
Genetic pathways that regulate ageing in model organisms
Leonard Guarente,Cynthia Kenyon +1 more
TL;DR: Genetic studies in genetically tractable model organisms established that ageing is indeed regulated by specific genes, and allowed an analysis of the pathways involved, linking physiology, signal transduction and gene regulation.
Journal ArticleDOI
Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway
TL;DR: It is shown that inhibition of TOR signaling pathway by alteration of the expression of genes in this nutrient-sensing pathway, which is conserved from yeast to human, extends lifespan in a manner that may overlap with known effects of dietary restriction on longevity.
Journal ArticleDOI
Calorie restriction, SIRT1 and metabolism: understanding longevity
Laura Bordone,Leonard Guarente +1 more
TL;DR: Recent findings that are beginning to clarify the mechanisms by which CR results in longevity and robust health, which might open new avenues of therapy for diseases of ageing are summarized.
Journal ArticleDOI
Calorie restriction and aging: review of the literature and implications for studies in humans
TL;DR: The absence of adequate information on the effects of good-quality, calorie-restricted diets in nonobese humans reflects the difficulties involved in conducting long-term studies in an environment so conducive to overfeeding.
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