Lifespan and reproduction in Drosophila: New insights from nutritional geometry
Kwang Pum Lee,Stephen J. Simpson,Fiona J. Clissold,Robert C. Brooks,J. William O. Ballard,Phil W. Taylor,Nazaneen Soran,David Raubenheimer +7 more
TLDR
The use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster indicates a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein.Abstract:
Modest dietary restriction (DR) prolongs life in a wide range of organisms, spanning single-celled yeast to mammals. Here, we report the use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster. Caloric restriction (CR) was not responsible for extending lifespan in our experimental flies. Response surfaces for lifespan and fecundity were maximized at different protein–carbohydrate intakes, with longevity highest at a protein-to-carbohydrate ratio of 1:16 and egg-laying rate maximized at 1:2. Lifetime egg production, the measure closest to fitness, was maximized at an intermediate P:C ratio of 1:4. Flies offered a choice of complementary foods regulated intake to maximize lifetime egg production. The results indicate a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein. We unite a body of apparently conflicting work within a common framework and provide a platform for studying aging in all organisms.read more
Citations
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Patterns and processes of human life history evolution
TL;DR: The key endocrinological mediators of life history trade-offs, particularly those involving reproduction, are emphasized.
Journal ArticleDOI
Food intake and food choice are altered by the developmental transition at critical weight in Drosophila melanogaster
TL;DR: The results show that the developmental transition at critical weight modifies larval feeding behaviour, increasing the understanding of how developmental processes influence behaviour.
Journal ArticleDOI
Ecological immunology mediated by diet in herbivorous insects.
TL;DR: The hypothesis that a diet-mediated defense by the host against parasites acts as a temporally explicit, multi-stage process is synthesized to generate the idea that nutritional influences the quality and quantity of immunological defense in herbivorous insects.
Journal ArticleDOI
Sex-specific transcriptomic responses to changes in the nutritional environment.
TL;DR: The results suggest that nutrient sensing output emanating from a shared metabolic machinery are reversed in Males and females, leading to opposing diet-dependent regulation of reproduction in males and females.
Journal ArticleDOI
Fibroblast growth factor 21 coordinates adiponectin to mediate the beneficial effects of low-protein diet on primordial follicle reserve.
Yong Zhuo,Lun Hua,Bin Feng,Xuemei Jiang,Jing Li,Dandan Jiang,Xiaohua Huang,Yingguo Zhu,Zhen Li,Lijun Yan,Chao Jin,Lianqiang Che,Zhengfeng Fang,Yan Lin,Shengyu Xu,Jian Li,De Wu +16 more
TL;DR: Dietary protein consumption controlled ovarian primordial follicle reserve and fertility, which required coordination between FGF21 and adiponectin, but instead required an adipokine adiponECTin.
References
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Book
The Retardation of Aging and Disease by Dietary Restriction
Richard Weindruch,Roy L. Walford +1 more
Journal ArticleDOI
Genetic pathways that regulate ageing in model organisms
Leonard Guarente,Cynthia Kenyon +1 more
TL;DR: Genetic studies in genetically tractable model organisms established that ageing is indeed regulated by specific genes, and allowed an analysis of the pathways involved, linking physiology, signal transduction and gene regulation.
Journal ArticleDOI
Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway
TL;DR: It is shown that inhibition of TOR signaling pathway by alteration of the expression of genes in this nutrient-sensing pathway, which is conserved from yeast to human, extends lifespan in a manner that may overlap with known effects of dietary restriction on longevity.
Journal ArticleDOI
Calorie restriction, SIRT1 and metabolism: understanding longevity
Laura Bordone,Leonard Guarente +1 more
TL;DR: Recent findings that are beginning to clarify the mechanisms by which CR results in longevity and robust health, which might open new avenues of therapy for diseases of ageing are summarized.
Journal ArticleDOI
Calorie restriction and aging: review of the literature and implications for studies in humans
TL;DR: The absence of adequate information on the effects of good-quality, calorie-restricted diets in nonobese humans reflects the difficulties involved in conducting long-term studies in an environment so conducive to overfeeding.
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