Lifespan and reproduction in Drosophila: New insights from nutritional geometry
Kwang Pum Lee,Stephen J. Simpson,Fiona J. Clissold,Robert C. Brooks,J. William O. Ballard,Phil W. Taylor,Nazaneen Soran,David Raubenheimer +7 more
TLDR
The use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster indicates a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein.Abstract:
Modest dietary restriction (DR) prolongs life in a wide range of organisms, spanning single-celled yeast to mammals. Here, we report the use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster. Caloric restriction (CR) was not responsible for extending lifespan in our experimental flies. Response surfaces for lifespan and fecundity were maximized at different protein–carbohydrate intakes, with longevity highest at a protein-to-carbohydrate ratio of 1:16 and egg-laying rate maximized at 1:2. Lifetime egg production, the measure closest to fitness, was maximized at an intermediate P:C ratio of 1:4. Flies offered a choice of complementary foods regulated intake to maximize lifetime egg production. The results indicate a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein. We unite a body of apparently conflicting work within a common framework and provide a platform for studying aging in all organisms.read more
Citations
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Role of TOR signaling in aging and related biological processes in Drosophila melanogaster.
Subhash D. Katewa,Pankaj Kapahi +1 more
TL;DR: Drosophila was the first organism where the nutrient dependent effects of the TOR pathway on lifespan were first uncovered and the nutrient-sensing TOR pathway appears to be critically important for mediating the longevity effects of dietary restriction (DR), a potent environmental method of lifespan extension by nutrient limitation.
Journal ArticleDOI
Fallback Foods, Optimal Diets, and Nutritional Targets: Primate Responses to Varying Food Availability and Quality
TL;DR: The variables that influence primate feeding preference: food availability, chemical defense, and nutrient content are explored and it is concluded that “fallback” is not an intrinsic state of the food or the consumer and that this conclusion complicates the application of this concept to feeding models.
Journal ArticleDOI
Effects of dietary restriction on mortality and age-related phenotypes in the short-lived fish Nothobranchius furzeri.
Eva Terzibasi,Christel Lefrançois,Paolo Domenici,Nils Hartmann,Michael Graf,Alessandro Cellerino +5 more
TL;DR: Analysis of age‐dependent mortality revealed that DR reduced demographic rate of aging, but increased baseline mortality in the wild‐derived strain, and induced a paradoxical up‐regulation of glial fibrillary acidic protein in the brain.
Journal ArticleDOI
Sugars, senescence, and ageing in plants and heterotrophic organisms
TL;DR: The metabolic regulation of leaf senescence is compared with the effects of dietary restriction and similarities and differences in the signalling pathways are discussed, including the role of autophagy, TOR, TOR-related protein kinase-1, Sir2, and SnRK1.
Journal ArticleDOI
The nature of nutrition: a unifying framework
TL;DR: Having considered the implications of diet for individuals, it is shown that these effects can translate into the collective behaviour of groups and societies, and in turn ramify throughout food webs to influence the structure of ecosystems.
References
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Book
The Retardation of Aging and Disease by Dietary Restriction
Richard Weindruch,Roy L. Walford +1 more
Journal ArticleDOI
Genetic pathways that regulate ageing in model organisms
Leonard Guarente,Cynthia Kenyon +1 more
TL;DR: Genetic studies in genetically tractable model organisms established that ageing is indeed regulated by specific genes, and allowed an analysis of the pathways involved, linking physiology, signal transduction and gene regulation.
Journal ArticleDOI
Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway
TL;DR: It is shown that inhibition of TOR signaling pathway by alteration of the expression of genes in this nutrient-sensing pathway, which is conserved from yeast to human, extends lifespan in a manner that may overlap with known effects of dietary restriction on longevity.
Journal ArticleDOI
Calorie restriction, SIRT1 and metabolism: understanding longevity
Laura Bordone,Leonard Guarente +1 more
TL;DR: Recent findings that are beginning to clarify the mechanisms by which CR results in longevity and robust health, which might open new avenues of therapy for diseases of ageing are summarized.
Journal ArticleDOI
Calorie restriction and aging: review of the literature and implications for studies in humans
TL;DR: The absence of adequate information on the effects of good-quality, calorie-restricted diets in nonobese humans reflects the difficulties involved in conducting long-term studies in an environment so conducive to overfeeding.
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