Lifespan and reproduction in Drosophila: New insights from nutritional geometry
Kwang Pum Lee,Stephen J. Simpson,Fiona J. Clissold,Robert C. Brooks,J. William O. Ballard,Phil W. Taylor,Nazaneen Soran,David Raubenheimer +7 more
TLDR
The use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster indicates a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein.Abstract:
Modest dietary restriction (DR) prolongs life in a wide range of organisms, spanning single-celled yeast to mammals. Here, we report the use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster. Caloric restriction (CR) was not responsible for extending lifespan in our experimental flies. Response surfaces for lifespan and fecundity were maximized at different protein–carbohydrate intakes, with longevity highest at a protein-to-carbohydrate ratio of 1:16 and egg-laying rate maximized at 1:2. Lifetime egg production, the measure closest to fitness, was maximized at an intermediate P:C ratio of 1:4. Flies offered a choice of complementary foods regulated intake to maximize lifetime egg production. The results indicate a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein. We unite a body of apparently conflicting work within a common framework and provide a platform for studying aging in all organisms.read more
Citations
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Journal ArticleDOI
Match and mismatch: conservation physiology, nutritional ecology and the timescales of biological adaptation
TL;DR: The high-level similarities and differences between CP and NE are explored, identifying as central themes to both fields the multiple timescales over which animals adapt (and fail to adapt) to their environments, and the need for integrative models to study these processes.
Journal ArticleDOI
Matching Dietary Amino Acid Balance to the In Silico-Translated Exome Optimizes Growth and Reproduction without Cost to Lifespan
Matthew D.W. Piper,George A Soultoukis,Eric Blanc,Andrea Mesaros,Samantha L. Herbert,Paula Juricic,Xiaoli He,Ilian Atanassov,Hanna Salmonowicz,Mingyao Yang,Stephen J. Simpson,Carlos Ribeiro,Linda Partridge,Linda Partridge +13 more
TL;DR: It is shown for the fruit fly Drosophila melanogaster that such “exome-matched” diets are more satiating, enhance growth, and increase reproduction relative to non-matched diets, and early life fitness traits can be enhanced at low levels of dietary amino acids that do not impose a cost to lifespan.
Journal ArticleDOI
Ant workers die young and colonies collapse when fed a high-protein diet
TL;DR: It is shown that restriction to high-protein, low-carbohydrate diets decreased worker lifespan by up to 10-fold; reduction in lifespan on such diets was mainly due to elevated intake of protein rather than lack of carbohydrate, and only one day of exposure to a high- protein diet had dire consequences for workers and the colony.
Book ChapterDOI
Benefits and costs of parental care
TL;DR: This chapter addresses the control systems that translate cues perceived by the organism about costs and benefits allowing individuals to take decisions, and also explores how trade-offs need not be based on resources, and the relevance of cost-free resources.
Journal ArticleDOI
Diet-Microbiome Interactions in Health Are Controlled by Intestinal Nitrogen Source Constraints.
Andrew J. Holmes,Yi Vee Chew,Feyza Colakoglu,John B. Cliff,Eline Klaassens,Mark Read,Samantha M. Solon-Biet,Aisling C. McMahon,Aisling C. McMahon,Victoria C. Cogger,Victoria C. Cogger,Kari Ruohonen,David Raubenheimer,David G. Le Couteur,David G. Le Couteur,Stephen J. Simpson +15 more
TL;DR: It is shown that microbial community assembly is fundamentally shaped by a dichotomy in bacterial strategies to access nitrogen in the gut environment, and the pattern of dietary protein intake constrains the host-microbiome dynamic in ways that are common to a very broad range of diet manipulation strategies.
References
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Book
The Retardation of Aging and Disease by Dietary Restriction
Richard Weindruch,Roy L. Walford +1 more
Journal ArticleDOI
Genetic pathways that regulate ageing in model organisms
Leonard Guarente,Cynthia Kenyon +1 more
TL;DR: Genetic studies in genetically tractable model organisms established that ageing is indeed regulated by specific genes, and allowed an analysis of the pathways involved, linking physiology, signal transduction and gene regulation.
Journal ArticleDOI
Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway
TL;DR: It is shown that inhibition of TOR signaling pathway by alteration of the expression of genes in this nutrient-sensing pathway, which is conserved from yeast to human, extends lifespan in a manner that may overlap with known effects of dietary restriction on longevity.
Journal ArticleDOI
Calorie restriction, SIRT1 and metabolism: understanding longevity
Laura Bordone,Leonard Guarente +1 more
TL;DR: Recent findings that are beginning to clarify the mechanisms by which CR results in longevity and robust health, which might open new avenues of therapy for diseases of ageing are summarized.
Journal ArticleDOI
Calorie restriction and aging: review of the literature and implications for studies in humans
TL;DR: The absence of adequate information on the effects of good-quality, calorie-restricted diets in nonobese humans reflects the difficulties involved in conducting long-term studies in an environment so conducive to overfeeding.
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