Lifespan and reproduction in Drosophila: New insights from nutritional geometry
Kwang Pum Lee,Stephen J. Simpson,Fiona J. Clissold,Robert C. Brooks,J. William O. Ballard,Phil W. Taylor,Nazaneen Soran,David Raubenheimer +7 more
TLDR
The use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster indicates a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein.Abstract:
Modest dietary restriction (DR) prolongs life in a wide range of organisms, spanning single-celled yeast to mammals. Here, we report the use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster. Caloric restriction (CR) was not responsible for extending lifespan in our experimental flies. Response surfaces for lifespan and fecundity were maximized at different protein–carbohydrate intakes, with longevity highest at a protein-to-carbohydrate ratio of 1:16 and egg-laying rate maximized at 1:2. Lifetime egg production, the measure closest to fitness, was maximized at an intermediate P:C ratio of 1:4. Flies offered a choice of complementary foods regulated intake to maximize lifetime egg production. The results indicate a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein. We unite a body of apparently conflicting work within a common framework and provide a platform for studying aging in all organisms.read more
Citations
More filters
Journal ArticleDOI
Dietary Restriction Depends on Nutrient Composition to Extend Chronological Lifespan in Budding Yeast Saccharomyces cerevisiae
TL;DR: The results indicate that lifespan extension by a typical dietary restriction regime was dependent on the nutrients in media and that nutrient composition was a key determinant for yeast longevity, and support the notion that nutrient compositions might be a more effective way than simple dietary restriction to optimize lifespan and biomass production from yeast to other organisms.
Journal ArticleDOI
Nutritional physiology of life-history trade-offs: how food protein–carbohydrate content influences life-history traits in the wing-polymorphic cricket Gryllus firmus
TL;DR: This is the first study to show how the concentration and ratio of dietary protein and carbohydrate affects consumption and allocation to key physiological features associated with the reproduction–dispersal life-history trade-off.
Journal ArticleDOI
Collective foraging in spatially complex nutritional environments
Mathieu Lihoreau,Michael A. Charleston,Alistair M. Senior,Fiona J. Clissold,Fiona J. Clissold,David Raubenheimer,David Raubenheimer,Stephen J. Simpson,Stephen J. Simpson,Jerome Buhl +9 more
TL;DR: An individual-based model integrating key concepts of nutritional geometry, collective animal behaviour and spatial ecology is introduced to study the nutritional behaviour of animal groups in large heterogeneous environments containing foods with different abundance, patchiness and nutritional composition.
Journal ArticleDOI
Nutritional geometry and fitness consequences in Drosophila suzukii, the Spotted-Wing Drosophila.
TL;DR: The preference–performance hypothesis (PPH), in which females are predicted to oviposit on medias that provide the greatest offspring benefits, is explored, in regard to its relevance in D. suzukii behavior and consequences for management, and provides valuable insight into the ecology and evolution of this species.
Journal ArticleDOI
Life History Transitions at the Origins of Agriculture: A Model for Understanding How Niche Construction Impacts Human Growth, Demography and Health.
TL;DR: It is argued that the origins of agriculture involved profound transformations in human life history strategies, impacting both the availability of energy and the way that it was allocated between life history functions in the body.
References
More filters
Book
The Retardation of Aging and Disease by Dietary Restriction
Richard Weindruch,Roy L. Walford +1 more
Journal ArticleDOI
Genetic pathways that regulate ageing in model organisms
Leonard Guarente,Cynthia Kenyon +1 more
TL;DR: Genetic studies in genetically tractable model organisms established that ageing is indeed regulated by specific genes, and allowed an analysis of the pathways involved, linking physiology, signal transduction and gene regulation.
Journal ArticleDOI
Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway
TL;DR: It is shown that inhibition of TOR signaling pathway by alteration of the expression of genes in this nutrient-sensing pathway, which is conserved from yeast to human, extends lifespan in a manner that may overlap with known effects of dietary restriction on longevity.
Journal ArticleDOI
Calorie restriction, SIRT1 and metabolism: understanding longevity
Laura Bordone,Leonard Guarente +1 more
TL;DR: Recent findings that are beginning to clarify the mechanisms by which CR results in longevity and robust health, which might open new avenues of therapy for diseases of ageing are summarized.
Journal ArticleDOI
Calorie restriction and aging: review of the literature and implications for studies in humans
TL;DR: The absence of adequate information on the effects of good-quality, calorie-restricted diets in nonobese humans reflects the difficulties involved in conducting long-term studies in an environment so conducive to overfeeding.
Related Papers (5)
The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice.
Samantha M. Solon-Biet,Aisling C. McMahon,J. William O. Ballard,Kari Ruohonen,Lindsay E. Wu,Victoria C. Cogger,Alessandra Warren,Xin Huang,Nicolas Pichaud,Richard G. Melvin,Rahul Gokarn,Mamdouh Khalil,Nigel Turner,Gregory J. Cooney,David A. Sinclair,David A. Sinclair,David Raubenheimer,David G. Le Couteur,Stephen J. Simpson +18 more