Lifespan and reproduction in Drosophila: New insights from nutritional geometry
Kwang Pum Lee,Stephen J. Simpson,Fiona J. Clissold,Robert C. Brooks,J. William O. Ballard,Phil W. Taylor,Nazaneen Soran,David Raubenheimer +7 more
TLDR
The use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster indicates a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein.Abstract:
Modest dietary restriction (DR) prolongs life in a wide range of organisms, spanning single-celled yeast to mammals. Here, we report the use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster. Caloric restriction (CR) was not responsible for extending lifespan in our experimental flies. Response surfaces for lifespan and fecundity were maximized at different protein–carbohydrate intakes, with longevity highest at a protein-to-carbohydrate ratio of 1:16 and egg-laying rate maximized at 1:2. Lifetime egg production, the measure closest to fitness, was maximized at an intermediate P:C ratio of 1:4. Flies offered a choice of complementary foods regulated intake to maximize lifetime egg production. The results indicate a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein. We unite a body of apparently conflicting work within a common framework and provide a platform for studying aging in all organisms.read more
Citations
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Review: can diet influence the selective advantage of mitochondrial DNA haplotypes?
TL;DR: This review explores the potential for changes in dietary macronutrients to differentially influence mitochondrial bioenergetics and thereby the frequency of mtDNA haplotypes in natural populations and considers specific interactions between diet and complex I of the mitochondrial ETS.
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Sexually dimorphic effects of dietary sugar on lifespan, feeding and starvation resistance in Drosophila.
TL;DR: Differences between Drosophila sexes in their responses to sugar-rich diets are revealed, indicating the fruit fly could be used as a model to understand the sexually dimorphic features of human metabolic health.
Primate nutritional ecology: The role of food selection, energy intake, and nutrient balancing in Mexican black howler monkey (Alouatta pigra) foraging strategies
TL;DR: This dissertation examined the nutritional ecology of Mexican black howler monkeys (Alouatta pigra), an endangered nonhuman primate species characterized by a high intraspecific variability in time spent feeding on leaves, fruits, flowers, and other items across seasons and study sites.
Journal ArticleDOI
Sex-Specific Effect of Juvenile Diet on Adult Disease Resistance in a Field Cricket
Clint D. Kelly,Brittany R. Tawes +1 more
TL;DR: The findings suggest that increased immune function might provide an explanation for the sexually-dimorphic increase in longevity generally observed in diet-restricted animals.
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Transcriptomic dissection of sexual differences in Bemisia tabaci , an invasive agricultural pest worldwide
Wen Xie,Litao Guo,Xiaoguo Jiao,Nina Yang,Xin Yang,Qingjun Wu,Shaoli Wang,Xuguo Zhou,Youjun Zhang +8 more
TL;DR: The gender difference in the sweetpotato whitefly Bemisia tabaci was investigated using Illumina-based transcriptomic analysis, and a putative transformer2 gene was cloned, and the structural feature and expression profile of tra2 were investigated.
References
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Book
The Retardation of Aging and Disease by Dietary Restriction
Richard Weindruch,Roy L. Walford +1 more
Journal ArticleDOI
Genetic pathways that regulate ageing in model organisms
Leonard Guarente,Cynthia Kenyon +1 more
TL;DR: Genetic studies in genetically tractable model organisms established that ageing is indeed regulated by specific genes, and allowed an analysis of the pathways involved, linking physiology, signal transduction and gene regulation.
Journal ArticleDOI
Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway
TL;DR: It is shown that inhibition of TOR signaling pathway by alteration of the expression of genes in this nutrient-sensing pathway, which is conserved from yeast to human, extends lifespan in a manner that may overlap with known effects of dietary restriction on longevity.
Journal ArticleDOI
Calorie restriction, SIRT1 and metabolism: understanding longevity
Laura Bordone,Leonard Guarente +1 more
TL;DR: Recent findings that are beginning to clarify the mechanisms by which CR results in longevity and robust health, which might open new avenues of therapy for diseases of ageing are summarized.
Journal ArticleDOI
Calorie restriction and aging: review of the literature and implications for studies in humans
TL;DR: The absence of adequate information on the effects of good-quality, calorie-restricted diets in nonobese humans reflects the difficulties involved in conducting long-term studies in an environment so conducive to overfeeding.
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