Lifespan and reproduction in Drosophila: New insights from nutritional geometry
Kwang Pum Lee,Stephen J. Simpson,Fiona J. Clissold,Robert C. Brooks,J. William O. Ballard,Phil W. Taylor,Nazaneen Soran,David Raubenheimer +7 more
TLDR
The use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster indicates a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein.Abstract:
Modest dietary restriction (DR) prolongs life in a wide range of organisms, spanning single-celled yeast to mammals. Here, we report the use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster. Caloric restriction (CR) was not responsible for extending lifespan in our experimental flies. Response surfaces for lifespan and fecundity were maximized at different protein–carbohydrate intakes, with longevity highest at a protein-to-carbohydrate ratio of 1:16 and egg-laying rate maximized at 1:2. Lifetime egg production, the measure closest to fitness, was maximized at an intermediate P:C ratio of 1:4. Flies offered a choice of complementary foods regulated intake to maximize lifetime egg production. The results indicate a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein. We unite a body of apparently conflicting work within a common framework and provide a platform for studying aging in all organisms.read more
Citations
More filters
Book ChapterDOI
Flight-fecundity tradeoffs in wing-monomorphic insects
TL;DR: Flight and fecundity in wing-monomorphic insects was related in a number of ways: via physiological constraints—resource-based tradeoffs—as well as via biomechanical constraints—when egg loads affected take-off performance—, due to adaptive negative correlations—when switching from flight to egg production if appropriate conditions to reproduce were encountered—and, dueto adaptive positive correlations— when optimal flight and high fecundities were favoured for colonizing new habitats.
Journal ArticleDOI
Does early-life diet affect longevity? A meta-analysis across experimental studies.
Sinead English,Tobias Uller +1 more
TL;DR: A meta-analysis across experimental studies manipulating pre- or post-natal diet and measuring longevity found no overall effect of early diet on lifespan, consistent with the prediction that early diet restriction disrupts growth and results in increased somatic damage, which incurs lifespan costs.
Journal ArticleDOI
The 4E-BP growth pathway regulates the effect of ambient temperature on Drosophila metabolism and lifespan.
Gil B. Carvalho,Ilaria Drago,Sany Hoxha,Ryuichi Yamada,Olena Mahneva,Kimberley D. Bruce,Alina Soto Obando,Bruno Conti,William W. Ja +8 more
TL;DR: It is shown that 4E-BP determines Drosophila lifespan in the context of temperature changes, revealing a genetic mechanism for cold-induced longevity in this model organism and suggesting that the 4 E-BP pathway, chiefly thought of as a nutrient sensor, may represent a master metabolic switch responding to diverse environmental factors.
Journal ArticleDOI
Adaptive dynamics of competition for nutritionally complementary resources: character convergence, displacement, and parallelism.
David A. Vasseur,Jeremy W. Fox +1 more
TL;DR: It is shown that incorporating costs of consuming or excreting excess nonlimiting nutrients selects for nutritionally balanced diets and so promotes character convergence, and highlights the importance of using mathematical models to infer the stability of ecoevolutionary dynamics.
Journal ArticleDOI
Lifespan Extension Via Dietary Restriction: Time to Reconsider the Evolutionary Mechanisms?
TL;DR: In the authors’ opinion, none of the current evolutionary explanations of DR adequately explain the intricacies of observed results; instead a context‐dependent combination of these theories is suggested which is likely to reflect reality.
References
More filters
Book
The Retardation of Aging and Disease by Dietary Restriction
Richard Weindruch,Roy L. Walford +1 more
Journal ArticleDOI
Genetic pathways that regulate ageing in model organisms
Leonard Guarente,Cynthia Kenyon +1 more
TL;DR: Genetic studies in genetically tractable model organisms established that ageing is indeed regulated by specific genes, and allowed an analysis of the pathways involved, linking physiology, signal transduction and gene regulation.
Journal ArticleDOI
Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway
TL;DR: It is shown that inhibition of TOR signaling pathway by alteration of the expression of genes in this nutrient-sensing pathway, which is conserved from yeast to human, extends lifespan in a manner that may overlap with known effects of dietary restriction on longevity.
Journal ArticleDOI
Calorie restriction, SIRT1 and metabolism: understanding longevity
Laura Bordone,Leonard Guarente +1 more
TL;DR: Recent findings that are beginning to clarify the mechanisms by which CR results in longevity and robust health, which might open new avenues of therapy for diseases of ageing are summarized.
Journal ArticleDOI
Calorie restriction and aging: review of the literature and implications for studies in humans
TL;DR: The absence of adequate information on the effects of good-quality, calorie-restricted diets in nonobese humans reflects the difficulties involved in conducting long-term studies in an environment so conducive to overfeeding.
Related Papers (5)
The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice.
Samantha M. Solon-Biet,Aisling C. McMahon,J. William O. Ballard,Kari Ruohonen,Lindsay E. Wu,Victoria C. Cogger,Alessandra Warren,Xin Huang,Nicolas Pichaud,Richard G. Melvin,Rahul Gokarn,Mamdouh Khalil,Nigel Turner,Gregory J. Cooney,David A. Sinclair,David A. Sinclair,David Raubenheimer,David G. Le Couteur,Stephen J. Simpson +18 more