Lifespan and reproduction in Drosophila: New insights from nutritional geometry
Kwang Pum Lee,Stephen J. Simpson,Fiona J. Clissold,Robert C. Brooks,J. William O. Ballard,Phil W. Taylor,Nazaneen Soran,David Raubenheimer +7 more
TLDR
The use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster indicates a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein.Abstract:
Modest dietary restriction (DR) prolongs life in a wide range of organisms, spanning single-celled yeast to mammals. Here, we report the use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster. Caloric restriction (CR) was not responsible for extending lifespan in our experimental flies. Response surfaces for lifespan and fecundity were maximized at different protein–carbohydrate intakes, with longevity highest at a protein-to-carbohydrate ratio of 1:16 and egg-laying rate maximized at 1:2. Lifetime egg production, the measure closest to fitness, was maximized at an intermediate P:C ratio of 1:4. Flies offered a choice of complementary foods regulated intake to maximize lifetime egg production. The results indicate a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein. We unite a body of apparently conflicting work within a common framework and provide a platform for studying aging in all organisms.read more
Citations
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How to get the most bang for your buck: the evolution and physiology of nutrition-dependent resource allocation strategies
TL;DR: It is argued that an integrated framework can reconcile evolutionary models with proximate mechanisms that appear at first glance to be in conflict with these models.
Journal ArticleDOI
Macronutrient intake regulates sexual conflict in decorated crickets
James Rapkin,Kim Jensen,Kim Jensen,Sarah M. Lane,Clarissa M. House,Scott K. Sakaluk,Scott K. Sakaluk,John Hunt +7 more
TL;DR: It is demonstrated that a balanced intake of nutrients is central to regulating sexual conflict in G. sigillatus, but males are constrained from reaching the optima needed to bias the outcome of this conflict in their favour.
Journal ArticleDOI
Effects of Non-Protein Amino Acids in Nectar on Bee Survival and Behavior
Gherardo Bogo,Gherardo Bogo,Laura Bortolotti,Simona Sagona,Antonio Felicioli,Marta Galloni,Marta Barberis,Massimo Nepi +7 more
TL;DR: Testing the effects of diets with low and high concentrations of γ-amino butyric acid (GABA) and β-alanine on the survival and behavior of Bombus terrestris and Apis mellifera found that pollinator intake of NPAAs may have important behavioral/ecological implications.
Journal ArticleDOI
Aging, Life Span, and Energetics under Adult Dietary Restriction in Lepidoptera
TL;DR: It is suggested that flight capacity is conserved during nutritional stress but that investment in flight and survival may negatively affect other important physiological processes when resources are limited.
Journal ArticleDOI
Reconciling nutritional geometry with classical dietary restriction: Effects of nutrient intake, not calories, on survival and reproduction.
Joshua P. Moatt,Murray A. Fyfe,Elizabeth Heap,Luke J. M. Mitchell,Fiona Moon,Craig A. Walling +5 more
TL;DR: The results provide the first evidence that macronutrient, not caloric, intake predicts changes in mortality and reproduction in the absence of dietary dilution, and supports the suggestion of evolutionary conservation in the effect of diet on lifespan, but via variation in macronsutrient intake rather than calories.
References
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Book
The Retardation of Aging and Disease by Dietary Restriction
Richard Weindruch,Roy L. Walford +1 more
Journal ArticleDOI
Genetic pathways that regulate ageing in model organisms
Leonard Guarente,Cynthia Kenyon +1 more
TL;DR: Genetic studies in genetically tractable model organisms established that ageing is indeed regulated by specific genes, and allowed an analysis of the pathways involved, linking physiology, signal transduction and gene regulation.
Journal ArticleDOI
Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway
TL;DR: It is shown that inhibition of TOR signaling pathway by alteration of the expression of genes in this nutrient-sensing pathway, which is conserved from yeast to human, extends lifespan in a manner that may overlap with known effects of dietary restriction on longevity.
Journal ArticleDOI
Calorie restriction, SIRT1 and metabolism: understanding longevity
Laura Bordone,Leonard Guarente +1 more
TL;DR: Recent findings that are beginning to clarify the mechanisms by which CR results in longevity and robust health, which might open new avenues of therapy for diseases of ageing are summarized.
Journal ArticleDOI
Calorie restriction and aging: review of the literature and implications for studies in humans
TL;DR: The absence of adequate information on the effects of good-quality, calorie-restricted diets in nonobese humans reflects the difficulties involved in conducting long-term studies in an environment so conducive to overfeeding.
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