Lifespan and reproduction in Drosophila: New insights from nutritional geometry
Kwang Pum Lee,Stephen J. Simpson,Fiona J. Clissold,Robert C. Brooks,J. William O. Ballard,Phil W. Taylor,Nazaneen Soran,David Raubenheimer +7 more
TLDR
The use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster indicates a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein.Abstract:
Modest dietary restriction (DR) prolongs life in a wide range of organisms, spanning single-celled yeast to mammals. Here, we report the use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutrient intake, lifespan, and reproduction in Drosophila melanogaster. Caloric restriction (CR) was not responsible for extending lifespan in our experimental flies. Response surfaces for lifespan and fecundity were maximized at different protein–carbohydrate intakes, with longevity highest at a protein-to-carbohydrate ratio of 1:16 and egg-laying rate maximized at 1:2. Lifetime egg production, the measure closest to fitness, was maximized at an intermediate P:C ratio of 1:4. Flies offered a choice of complementary foods regulated intake to maximize lifetime egg production. The results indicate a role for both direct costs of reproduction and other deleterious consequences of ingesting high levels of protein. We unite a body of apparently conflicting work within a common framework and provide a platform for studying aging in all organisms.read more
Citations
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Senescence in wild insects: Key questions and challenges
TL;DR: It is argued that the study of senescence in wild insects is important because many insights and hypotheses based on laboratory experiments must be tested in natural populations, and it is believed that such work will shed light on many important questions in ecology and evolutionary biology.
Journal ArticleDOI
Genetic Dissection of Nutrition-Induced Plasticity in Insulin/Insulin-Like Growth Factor Signaling and Median Life Span in a Drosophila Multiparent Population.
TL;DR: A correlation between the discriminant function scores and the median life span provides evidence that gene expression changes in response to diet are associated with longevity in these RILs.
Journal ArticleDOI
Sexual dimorphism in the nutritional requirement for adult lifespan in Drosophila melanogaster.
Qi Wu,Guixiang Yu,Xingyi Cheng,Yue Gao,Xiaolan Fan,Deying Yang,Meng Xie,Tao Wang,Matthew D.W. Piper,Mingyao Yang +9 more
TL;DR: Female oogenesis rather than chromosomal karyotype and mating status is the key cause of this gender difference in life‐sustaining nutritional requirements, which is important to the way the mechanisms by which diet modifies lifespan are understood.
Journal ArticleDOI
Caterpillars use developmental plasticity and diet choice to overcome the early life experience of nutritional imbalance
TL;DR: The results suggest that caterpillars are not only capable of switching their developmental program to reduce the deleterious effects of an early deficiency of protein, but also flexible at adjusting nutrient preferences to redress specific nutritional imbalances experienced early in life.
Journal ArticleDOI
Influence of two methods of dietary restriction on life history features and aging of the cricket Acheta domesticus
TL;DR: The cricket is validated as a model of aging by testing two fundamental methods of restricting food intake: time-restricted access to food and dietary dilution and growth, maturation, survivorship, and longevity varied with treatments and genders.
References
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Book
The Retardation of Aging and Disease by Dietary Restriction
Richard Weindruch,Roy L. Walford +1 more
Journal ArticleDOI
Genetic pathways that regulate ageing in model organisms
Leonard Guarente,Cynthia Kenyon +1 more
TL;DR: Genetic studies in genetically tractable model organisms established that ageing is indeed regulated by specific genes, and allowed an analysis of the pathways involved, linking physiology, signal transduction and gene regulation.
Journal ArticleDOI
Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway
TL;DR: It is shown that inhibition of TOR signaling pathway by alteration of the expression of genes in this nutrient-sensing pathway, which is conserved from yeast to human, extends lifespan in a manner that may overlap with known effects of dietary restriction on longevity.
Journal ArticleDOI
Calorie restriction, SIRT1 and metabolism: understanding longevity
Laura Bordone,Leonard Guarente +1 more
TL;DR: Recent findings that are beginning to clarify the mechanisms by which CR results in longevity and robust health, which might open new avenues of therapy for diseases of ageing are summarized.
Journal ArticleDOI
Calorie restriction and aging: review of the literature and implications for studies in humans
TL;DR: The absence of adequate information on the effects of good-quality, calorie-restricted diets in nonobese humans reflects the difficulties involved in conducting long-term studies in an environment so conducive to overfeeding.
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