Journal ArticleDOI
Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm.
TLDR
It is suggested that on the distal portion of the nonfluorescent segment of the long arm of the Y, factors are located controlling spermatogenesis.Abstract:
A deletion of the Y chromosome at the distal portion of band q11 was found in 6 men with normal male habitus but with azoospermia. Five of them were found during a survey of 1170 subfertile males while the sixth was karyotyped because of slight bone abnormalities. These findings, together with a review of the literature, suggest that on the distal portion of the nonfluorescent segment of the long arm of the Y, factors are located controlling spermatogenesis.read more
Citations
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Journal ArticleDOI
Lower total motile count is associated with smaller historic intergenerational family size: a pedigree analysis from the Utah Population Database
Darshan P. Patel,H. Meeks,Heidi A. Hanson,Heidi A. Hanson,Alexander W. Pastuszak,James M. Hotaling,Ken R. Smith,Ken R. Smith +7 more
TL;DR: In this paper, the association between contemporary total motile count (TMC), a measure of male factor infertility, and historic intergenerational family size was described, and a retrospective, population-based, cohort study of men who underwent semen analysis for infertility workup at University of Utah, who were linked to extensive genealogical data was conducted.
Journal ArticleDOI
Fécondation assistée par micro injection des spermatides: Etat des lieux et questions posées
TL;DR: The use of ICSI with round or elongated spermatids, a new therapeutic approach of different forms of male sterility including obstructive and sperMatogenic failure azoospermia is reviewed.
Journal ArticleDOI
Genetische Grundlagen der andrologischen Subfertilität
TL;DR: The major genetic causes of male subfertility are presented and the corresponding practical consequences for the clinic discussed, and the häufigsten genetischen Ursachen der männlichen Subfertilität vorgestellt and die sich daraus ergebenden Konsequenzen f for the Klinik diskutiert.
Book ChapterDOI
Genomic Landscape of Human Y Chromosome and Male Infertility
Vertika Singh,Kiran Singh +1 more
TL;DR: The whole genome and transcriptome analysis of Y chromosome across different species have shed light on the origin, comparative gene content, and long-term providence of this interesting chromosome.
Emerging molecular methods for male infertility
Moncef Benkhalifa,Debbie Montjean,S. Belloc,Alain Dalleac,Michel Ducasse,Pierre Boyer,Philippe Merviel,Henri Copin +7 more
TL;DR: Karyotyping and FISH application at somatic and germ cell levels are no longer sufficient to investigate the potential contribution of genome disorders on male infertility and a wide range of molecular methods are required for better understanding of male infertility causes.
References
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Journal ArticleDOI
A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities.
TL;DR: Data from a chromosome examination of 14,069 consecutive newborn infants is presented, finding 294 babies with a major chromosome abnormality or distinctive marker chromosomes.
Journal ArticleDOI
Possible role for H--Y antigen in the primary determination of sex.
TL;DR: The part that the X chromosome plays in male sexual differentiation has been clarified at the level of an individual gene situated on this chromosome.
Journal ArticleDOI
A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities
TL;DR: The results of the present study when combined with five other comparable studies, thus comprising a total of 46,150 newborn infants, indicates that the frequency of major chromosome abnormalities is between 1:150 and 1:200 live-born babies.
Journal ArticleDOI
Structural abnormalities of the Y chromosome in man.
Patricia A. Jacobs,A. Ross +1 more
Journal ArticleDOI
Chromosome polymorphism in a human newborn population. II. Potentials of polymorphic chromosome variants for characterizing the idiogram of an individual.
TL;DR: The baseline data presented here reinforce the view that polymorphic chromosome characteristics are very useful markers for characterizing the karyotype of an infant born at the Albert Einstein College Hospital, Bronx, New York, and are consistent with the expectations of the Hardy-Weinberg law.
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