Journal ArticleDOI
Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm.
TLDR
It is suggested that on the distal portion of the nonfluorescent segment of the long arm of the Y, factors are located controlling spermatogenesis.Abstract:
A deletion of the Y chromosome at the distal portion of band q11 was found in 6 men with normal male habitus but with azoospermia. Five of them were found during a survey of 1170 subfertile males while the sixth was karyotyped because of slight bone abnormalities. These findings, together with a review of the literature, suggest that on the distal portion of the nonfluorescent segment of the long arm of the Y, factors are located controlling spermatogenesis.read more
Citations
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Journal ArticleDOI
The expression of DAZL1 in the ovary of the human female fetus.
Meng-Yin Tsai,Shiuh-Young Chang,Hsin-Yi Lo,I-Hsuan Chen,F.-J. Huang,Fu-Tsai Kung,Ying-Jen Lu +6 more
TL;DR: DAZL1 is not only expressed in human testes but also in ovaries, and it may play a role in germ cell survival and gonad development in both sexes.
Journal ArticleDOI
Risk of transmission of genetic diseases by assisted reproduction.
TL;DR: The authors discuss the major advances in the ability to diagnose genetic defects in infertile males and the genes required for male fertility.
Journal ArticleDOI
Tracking microdeletions of the AZF region in a patrilineal line of infertile men.
TL;DR: The treatment with intracytoplasmic sperm injection can result in vertical transmission of microdeletions of the AZF region and can also cause the expansion of a de novo mutation.
Journal ArticleDOI
Azoospermia factor microdeletions: occurrence in infertile men with azoospermia and severe oligozoospermia from China
TL;DR: Investigating the frequencies of AZF microdeletions in 137 infertile males with azoospermia and severe oligozoospermia from Jilin province of China and analysing the relationship between the levels of reproductive hormones and AZFmicrodeletion found no significant correlation between theAZF micro deletion and the levelsof reproductive hormones.
Journal ArticleDOI
Routine diagnostic testing of Y chromosome deletions in male infertile and subfertile.
TL;DR: With the analysis of Yq deletions, a better understanding of the clinical significance of genetic anomaly is obtained and to the identifying of fertility candidate genes in the AZF regions is obtained.
References
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Journal ArticleDOI
A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities.
TL;DR: Data from a chromosome examination of 14,069 consecutive newborn infants is presented, finding 294 babies with a major chromosome abnormality or distinctive marker chromosomes.
Journal ArticleDOI
Possible role for H--Y antigen in the primary determination of sex.
TL;DR: The part that the X chromosome plays in male sexual differentiation has been clarified at the level of an individual gene situated on this chromosome.
Journal ArticleDOI
A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities
TL;DR: The results of the present study when combined with five other comparable studies, thus comprising a total of 46,150 newborn infants, indicates that the frequency of major chromosome abnormalities is between 1:150 and 1:200 live-born babies.
Journal ArticleDOI
Structural abnormalities of the Y chromosome in man.
Patricia A. Jacobs,A. Ross +1 more
Journal ArticleDOI
Chromosome polymorphism in a human newborn population. II. Potentials of polymorphic chromosome variants for characterizing the idiogram of an individual.
TL;DR: The baseline data presented here reinforce the view that polymorphic chromosome characteristics are very useful markers for characterizing the karyotype of an infant born at the Albert Einstein College Hospital, Bronx, New York, and are consistent with the expectations of the Hardy-Weinberg law.
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