Journal ArticleDOI
Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm.
TLDR
It is suggested that on the distal portion of the nonfluorescent segment of the long arm of the Y, factors are located controlling spermatogenesis.Abstract:
A deletion of the Y chromosome at the distal portion of band q11 was found in 6 men with normal male habitus but with azoospermia. Five of them were found during a survey of 1170 subfertile males while the sixth was karyotyped because of slight bone abnormalities. These findings, together with a review of the literature, suggest that on the distal portion of the nonfluorescent segment of the long arm of the Y, factors are located controlling spermatogenesis.read more
Citations
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Journal ArticleDOI
Apples and oranges. Re: 7.4-year update of the ongoing bicalutamide Early Prostate Cancer (EPC) trial programme.
TL;DR: The authors conclude that bicalutamide is not useful in patients with localized disease, but recommend its use in Patients with locally advanced disease, as it significantly improves progression-free survival (PFS) irrespective of standard care.
Journal ArticleDOI
Y chromosome genes and male infertility.
TL;DR: It is not only important that patients understand the cause of their infertility, but also how these genes work together can elucidate of the exact cause of infertility in some patients once thought to have idiopathic infertility.
Book ChapterDOI
Post-transcriptional Control and Male Infertility
TL;DR: The search for message-specific RNA binding proteins has led to the discovery of several novel proteins that localize to different compartments in differentiating spermatogenic cells, and emerging genetic evidence suggests that these proteins have essential functions in developing germ cells.
Journal ArticleDOI
Characterization of a (Y;4) translocation by DNA hybridization.
TL;DR: It is concluded that DNA hybridization can be used to refine considerably the cytogenetic analysis of such translocations and could be characterized as t(Y;4)(pll;q32).
Journal ArticleDOI
The genetics of human reproduction.
TL;DR: The genetic approach to infections disease with special emphasis on the MHC and the evidence from /?S-globin gene cluster polymorphisms.
References
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Journal ArticleDOI
A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities.
TL;DR: Data from a chromosome examination of 14,069 consecutive newborn infants is presented, finding 294 babies with a major chromosome abnormality or distinctive marker chromosomes.
Journal ArticleDOI
Possible role for H--Y antigen in the primary determination of sex.
TL;DR: The part that the X chromosome plays in male sexual differentiation has been clarified at the level of an individual gene situated on this chromosome.
Journal ArticleDOI
A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities
TL;DR: The results of the present study when combined with five other comparable studies, thus comprising a total of 46,150 newborn infants, indicates that the frequency of major chromosome abnormalities is between 1:150 and 1:200 live-born babies.
Journal ArticleDOI
Structural abnormalities of the Y chromosome in man.
Patricia A. Jacobs,A. Ross +1 more
Journal ArticleDOI
Chromosome polymorphism in a human newborn population. II. Potentials of polymorphic chromosome variants for characterizing the idiogram of an individual.
TL;DR: The baseline data presented here reinforce the view that polymorphic chromosome characteristics are very useful markers for characterizing the karyotype of an infant born at the Albert Einstein College Hospital, Bronx, New York, and are consistent with the expectations of the Hardy-Weinberg law.
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