Journal ArticleDOI
Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm.
TLDR
It is suggested that on the distal portion of the nonfluorescent segment of the long arm of the Y, factors are located controlling spermatogenesis.Abstract:
A deletion of the Y chromosome at the distal portion of band q11 was found in 6 men with normal male habitus but with azoospermia. Five of them were found during a survey of 1170 subfertile males while the sixth was karyotyped because of slight bone abnormalities. These findings, together with a review of the literature, suggest that on the distal portion of the nonfluorescent segment of the long arm of the Y, factors are located controlling spermatogenesis.read more
Citations
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Journal ArticleDOI
Deletion mapping of H-Y antigen to the long arm of the human Y chromosome.
Michael A. Cantrell,Jonathan S. Bogan,Jonathan S. Bogan,Elizabeth M. Simpson,James N. Bicknell,Els Goulmy,Phillip Chandler,Roberta A. Pagon,David C. Walker,Horace C. Thuline,John M. Graham,Albert de la Chapelle,David C. Page,David C. Page,Christine M. Disteche +14 more
TL;DR: It is concluded that the H-Y antigen gene maps to a portion of deletion interval 6 that is identified by specific DNA markers.
Journal ArticleDOI
Study of microdeletions in the Y chromosome of infertile men with idiopathic oligo- or azoospermia.
TL;DR: To avoid transmission to their offspring, patients with idiopathic oligo- or azoospermia should be screened for microdeletions of the Y chromosome before ICSI treatment for infertility.
Journal ArticleDOI
A spontaneous smc1b mutation causes cohesin protein dysfunction and sterility in mice.
TL;DR: It was concluded that this deletion led to a frame-shift, which generated a stop codon at position 761 (amino acid 247) of the Smc1b cDNA in mutant mice, which causes female and male sterility.
Journal ArticleDOI
Microdeletion of the DAZ (deleted in azoospermia) gene or the YRRM (Y chromosome ribonucleic acid recognition motif) gene does not occur in patients with Klinefelter's syndrome with and without spermatogenesis.
T. Tateno,Isoji Sasagawa,Osamu Ichiyanagi,Junko Ashida,Teruhiro Nakada,Hidekazu Saito,Masahiko Hiroi +6 more
TL;DR: Severe impairment of spermatogenesis in patients with Klinefelter's syndrome is not caused by microdeletions of the Y chromosome involving the DAZ and YRRM genes.
Journal ArticleDOI
Embryo outcome in Y-chromosome microdeleted infertile males after ICSI
Paul E. Kihaile,Ramzy E. Kisanga,Kazuo Aoki,Yoko Kumasako,Junichi Misumi,Takafumi Utsunomiya +5 more
TL;DR: In Y‐chromosome microdeletion cycles in which sperm cells were available for intracytoplasmic sperm injection (ICSI), embryo outcome was comparable to conventional IVF, according to a prospective study involving 118 infertile Japanese couples.
References
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Journal ArticleDOI
A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities.
TL;DR: Data from a chromosome examination of 14,069 consecutive newborn infants is presented, finding 294 babies with a major chromosome abnormality or distinctive marker chromosomes.
Journal ArticleDOI
Possible role for H--Y antigen in the primary determination of sex.
TL;DR: The part that the X chromosome plays in male sexual differentiation has been clarified at the level of an individual gene situated on this chromosome.
Journal ArticleDOI
A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities
TL;DR: The results of the present study when combined with five other comparable studies, thus comprising a total of 46,150 newborn infants, indicates that the frequency of major chromosome abnormalities is between 1:150 and 1:200 live-born babies.
Journal ArticleDOI
Structural abnormalities of the Y chromosome in man.
Patricia A. Jacobs,A. Ross +1 more
Journal ArticleDOI
Chromosome polymorphism in a human newborn population. II. Potentials of polymorphic chromosome variants for characterizing the idiogram of an individual.
TL;DR: The baseline data presented here reinforce the view that polymorphic chromosome characteristics are very useful markers for characterizing the karyotype of an infant born at the Albert Einstein College Hospital, Bronx, New York, and are consistent with the expectations of the Hardy-Weinberg law.
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