Journal ArticleDOI
Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm.
TLDR
It is suggested that on the distal portion of the nonfluorescent segment of the long arm of the Y, factors are located controlling spermatogenesis.Abstract:
A deletion of the Y chromosome at the distal portion of band q11 was found in 6 men with normal male habitus but with azoospermia. Five of them were found during a survey of 1170 subfertile males while the sixth was karyotyped because of slight bone abnormalities. These findings, together with a review of the literature, suggest that on the distal portion of the nonfluorescent segment of the long arm of the Y, factors are located controlling spermatogenesis.read more
Citations
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Journal ArticleDOI
Y Chromosome (Yq11) Microdeletions in Idiopathic Azoospermia
Toshiro Shirakawa,Masato Fujisawa,Masanori Kanzaki,Hiroshi Okada,Soichi Arakawa,Sadao Kamidono +5 more
TL;DR: Cytogenetic anomalies and molecular deletions of the Y chromosome in idiopathically sterile men suggest that genetic factor(s) controlling spermatogenesis are located in the distal portion of Yq11.23 region in Idiopathic azoospermia.
Journal ArticleDOI
Engaging Practicing Gynecologists in the Management of Infertile Men
TL;DR: The initial counseling of azoospermic men by an andrologically well educated gynecologist may alleviate the misconception and distress surrounding the false belief of sterility, and will clarify the available options of percutaneous and microsurgical sperm-retrieval techniques and assisted conception outcome.
Journal ArticleDOI
Genetics of male infertility
TL;DR: Using pharmacological and molecular tools, it is determined that a PDE3 is the enzyme involved in the control of cAMP levels in the oocytes, and activation of a Pde is per se sufficient to cause resumption of meiosis in an amphibian oocyte model.
Journal ArticleDOI
Les méthodes de détection des microdélétions du chromosome Y : intérêt d’une nouvelle approche fondée sur la méthode d’électrophorèse en gradient de gel dénaturant
TL;DR: This review describes the molecular methods and laboratory guidelines for molecular diagnosis of Y-chromosomal microdeletions and suggests different molecular approaches should allow explaining 10% of male infertility, to evaluate the risk to pass the defect onto their male offspring and improve the genetic counselling of couples undergoing micromanipulative assisted reproduction.
Book ChapterDOI
Comparative Genomics of the Y Chromosome and Male Fertility
TL;DR: This chapter will review recent studies on functions and polymorphisms of the Y chromosome genes with a focus on the candidate genes for spermatogenesis and male fertility.
References
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Journal ArticleDOI
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TL;DR: Data from a chromosome examination of 14,069 consecutive newborn infants is presented, finding 294 babies with a major chromosome abnormality or distinctive marker chromosomes.
Journal ArticleDOI
Possible role for H--Y antigen in the primary determination of sex.
TL;DR: The part that the X chromosome plays in male sexual differentiation has been clarified at the level of an individual gene situated on this chromosome.
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A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities
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Journal ArticleDOI
Structural abnormalities of the Y chromosome in man.
Patricia A. Jacobs,A. Ross +1 more
Journal ArticleDOI
Chromosome polymorphism in a human newborn population. II. Potentials of polymorphic chromosome variants for characterizing the idiogram of an individual.
TL;DR: The baseline data presented here reinforce the view that polymorphic chromosome characteristics are very useful markers for characterizing the karyotype of an infant born at the Albert Einstein College Hospital, Bronx, New York, and are consistent with the expectations of the Hardy-Weinberg law.
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