Journal ArticleDOI
Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm.
TLDR
It is suggested that on the distal portion of the nonfluorescent segment of the long arm of the Y, factors are located controlling spermatogenesis.Abstract:
A deletion of the Y chromosome at the distal portion of band q11 was found in 6 men with normal male habitus but with azoospermia. Five of them were found during a survey of 1170 subfertile males while the sixth was karyotyped because of slight bone abnormalities. These findings, together with a review of the literature, suggest that on the distal portion of the nonfluorescent segment of the long arm of the Y, factors are located controlling spermatogenesis.read more
Citations
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Journal ArticleDOI
Incidence of microdeletions in the azf region of the y chromosome in slovak patients with azoospermia
Behulova R,Ivan Varga,Lubica Strhakova,Alexandra Bozikova,Dana Gabriková,Iveta Boronova,Vanda Repiská +6 more
TL;DR: The study confirmed that percentage of microdeletions in the AZF region of Y chromosome is low in Slovak azoospermic patients, but important from a prognostic view.
Journal ArticleDOI
A Screen for Genomic Disorders of Infertility Identifies MAST2 Duplications Associated with Nonobstructive Azoospermia in Humans
Ni Huang,Yang Wen,Xuejiang Guo,Zheng Li,Juncheng Dai,Bixian Ni,Jun Yu,Yuan Lin,Wen Zhou,Bing Yao,Yue Jiang,Jiahao Sha,Donald F. Conrad,Zhibin Hu +13 more
TL;DR: The results strongly support the previous claim that sperm production is modulated by genetic variation across the entire genome and identify 117 testis genes contained within 47 hotspots that may plausibly mediate genomic disorders of fertility.
Journal ArticleDOI
The evolutionary origins and consequences of self-fertility in nematodes.
Ronald E. Ellis,Shin-Yi Lin +1 more
TL;DR: Nematode mating systems are ideal for elucidating the origin of novel traits, and studying the influence of developmental processes on evolutionary change, in self-fertile hermaphrodites.
Journal ArticleDOI
Facts and considerations about sex-specific antigens.
TL;DR: Current hypotheses as to the function(s) and the genetic control of the sex-specific antigens are individually scrutinized and some prospects for further H-Y research are briefly suggested.
Journal ArticleDOI
The Prevalence of Y-chromosome Microdeletions in Oligozoospermic Men: A Systematic Review and Meta-analysis of European and North American Studies.
TL;DR: Male infertility guidelines for North America and Europe should reconsider the sperm concentration screening thresholds to recommend testing for YCMs only for men with sperm concentrations of <1 million sperm/ml.
References
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Journal ArticleDOI
A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities.
TL;DR: Data from a chromosome examination of 14,069 consecutive newborn infants is presented, finding 294 babies with a major chromosome abnormality or distinctive marker chromosomes.
Journal ArticleDOI
Possible role for H--Y antigen in the primary determination of sex.
TL;DR: The part that the X chromosome plays in male sexual differentiation has been clarified at the level of an individual gene situated on this chromosome.
Journal ArticleDOI
A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities
TL;DR: The results of the present study when combined with five other comparable studies, thus comprising a total of 46,150 newborn infants, indicates that the frequency of major chromosome abnormalities is between 1:150 and 1:200 live-born babies.
Journal ArticleDOI
Structural abnormalities of the Y chromosome in man.
Patricia A. Jacobs,A. Ross +1 more
Journal ArticleDOI
Chromosome polymorphism in a human newborn population. II. Potentials of polymorphic chromosome variants for characterizing the idiogram of an individual.
TL;DR: The baseline data presented here reinforce the view that polymorphic chromosome characteristics are very useful markers for characterizing the karyotype of an infant born at the Albert Einstein College Hospital, Bronx, New York, and are consistent with the expectations of the Hardy-Weinberg law.
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