Journal ArticleDOI
Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm.
TLDR
It is suggested that on the distal portion of the nonfluorescent segment of the long arm of the Y, factors are located controlling spermatogenesis.Abstract:
A deletion of the Y chromosome at the distal portion of band q11 was found in 6 men with normal male habitus but with azoospermia. Five of them were found during a survey of 1170 subfertile males while the sixth was karyotyped because of slight bone abnormalities. These findings, together with a review of the literature, suggest that on the distal portion of the nonfluorescent segment of the long arm of the Y, factors are located controlling spermatogenesis.read more
Citations
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Journal ArticleDOI
MSY Breakpoint Mapper, a database of sequence-tagged sites useful in defining naturally occurring deletions in the human Y chromosome
TL;DR: A database of Y-chromosomal DNA markers, or sequence-tagged sites, is compiled, useful for efficiently and systematically defining the breakpoint(s) of virtually any naturally occurring Y chromosome deletion.
Journal ArticleDOI
Interstitial deletion involving most of Yq.
James Skare,Helen Drwinga,Herman E. Wyandt,Johanna C. vanderSpek,Robert F. Troxler,Aubrey Milunsky +5 more
TL;DR: An analysis of cells obtained from a college student with azoospermia, short stature, and a small penis concludes that the deletion of Yq12 is interstitial.
Journal ArticleDOI
Copy number variation in the human Y chromosome in the UK population
Wei Wei,Tomas W Fitzgerald,Qasim Ayub,Andrea Massaia,Blair H. Smith,Anna F. Dominiczak,Andrew D. Morris,David D Porteous,Matthew E. Hurles,Chris Tyler-Smith,Yali Xue +10 more
TL;DR: Assessment of copy number variation in the male-specific part of the human Y chromosome discovered by array comparative genomic hybridization (array-CGH) in 411 apparently healthy UK males found nine showed CNV, including a large duplication encompassing the AMELY and TBL1Y genes that probably has no phenotypic effect.
Journal ArticleDOI
A 45,X male with translocation of euchromatic Y chromosome material
TL;DR: A phenotypically normal 32-year-old male with azoospermia was found to have a 45,X karyotype with presence of excess euchromatic material on 14p, interpreted as a Y/14 translocation with loss of the heterochromatic Y chromosome material.
Journal ArticleDOI
The role of food supplementation in the treatment of the infertile couple and for assisted reproduction.
TL;DR: There is strong evidence that complementary treatment with an appropriate nutraceutical improves the natural conception rate of infertile couples and increases the success rate of assisted reproductive techniques.
References
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Journal ArticleDOI
A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities.
TL;DR: Data from a chromosome examination of 14,069 consecutive newborn infants is presented, finding 294 babies with a major chromosome abnormality or distinctive marker chromosomes.
Journal ArticleDOI
Possible role for H--Y antigen in the primary determination of sex.
TL;DR: The part that the X chromosome plays in male sexual differentiation has been clarified at the level of an individual gene situated on this chromosome.
Journal ArticleDOI
A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities
TL;DR: The results of the present study when combined with five other comparable studies, thus comprising a total of 46,150 newborn infants, indicates that the frequency of major chromosome abnormalities is between 1:150 and 1:200 live-born babies.
Journal ArticleDOI
Structural abnormalities of the Y chromosome in man.
Patricia A. Jacobs,A. Ross +1 more
Journal ArticleDOI
Chromosome polymorphism in a human newborn population. II. Potentials of polymorphic chromosome variants for characterizing the idiogram of an individual.
TL;DR: The baseline data presented here reinforce the view that polymorphic chromosome characteristics are very useful markers for characterizing the karyotype of an infant born at the Albert Einstein College Hospital, Bronx, New York, and are consistent with the expectations of the Hardy-Weinberg law.
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