Journal ArticleDOI
Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm.
TLDR
It is suggested that on the distal portion of the nonfluorescent segment of the long arm of the Y, factors are located controlling spermatogenesis.Abstract:
A deletion of the Y chromosome at the distal portion of band q11 was found in 6 men with normal male habitus but with azoospermia. Five of them were found during a survey of 1170 subfertile males while the sixth was karyotyped because of slight bone abnormalities. These findings, together with a review of the literature, suggest that on the distal portion of the nonfluorescent segment of the long arm of the Y, factors are located controlling spermatogenesis.read more
Citations
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Journal ArticleDOI
Y chromosome microdeletion screening in infertile men in France:a survey of French practice based on 88 IVF centres
TL;DR: It seems necessary for a consensus to be reached on indications with a view to a standardized technique, with a common effort of experts in the field, for Y chromosome microdeletion screening, in France.
Journal ArticleDOI
Y chromosome instability in testicular cancer.
TL;DR: Genetic factors such as malfunction of metabolizing genes, DNA repairing genes, Y-linked or X-linked genes have been considered as possible causes of AZF deletions in testicular cancer, yet the exact identification of the genes involved remains elusive.
Journal ArticleDOI
Establishing reproductive potential and advances in fertility preservation techniques for XY individuals with differences in sex development.
Rumana Islam,Sheila Lane,Suzannah A. Williams,Christian M. Becker,Gerard S. Conway,Sarah M. Creighton +5 more
TL;DR: The use of fertility preservation techniques could be expanded to include individuals with DSD where functioning gonads are present and, where gonadectomy forms part of management, is often discarded.
Journal ArticleDOI
Genetic disorders and infertility.
TL;DR: It is critical for the urologist who evaluates and treats infertile couples to have a working knowledge of these disorders and an understanding of the genetic basis of male infertility allows for the appropriate counseling of patients about treatment options and risks to their potential offspring.
Journal ArticleDOI
A deletion of heterochromatin only of the Y chromosome in an azoospermic male
TL;DR: A patient with a deletion of the distal portion of the long arm (q21) of chromosome Y is described clinically and cytogenetically and the results suggest that no Y euchromatin was lost.
References
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Journal ArticleDOI
A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities.
TL;DR: Data from a chromosome examination of 14,069 consecutive newborn infants is presented, finding 294 babies with a major chromosome abnormality or distinctive marker chromosomes.
Journal ArticleDOI
Possible role for H--Y antigen in the primary determination of sex.
TL;DR: The part that the X chromosome plays in male sexual differentiation has been clarified at the level of an individual gene situated on this chromosome.
Journal ArticleDOI
A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities
TL;DR: The results of the present study when combined with five other comparable studies, thus comprising a total of 46,150 newborn infants, indicates that the frequency of major chromosome abnormalities is between 1:150 and 1:200 live-born babies.
Journal ArticleDOI
Structural abnormalities of the Y chromosome in man.
Patricia A. Jacobs,A. Ross +1 more
Journal ArticleDOI
Chromosome polymorphism in a human newborn population. II. Potentials of polymorphic chromosome variants for characterizing the idiogram of an individual.
TL;DR: The baseline data presented here reinforce the view that polymorphic chromosome characteristics are very useful markers for characterizing the karyotype of an infant born at the Albert Einstein College Hospital, Bronx, New York, and are consistent with the expectations of the Hardy-Weinberg law.
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