Journal ArticleDOI
Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm.
TLDR
It is suggested that on the distal portion of the nonfluorescent segment of the long arm of the Y, factors are located controlling spermatogenesis.Abstract:
A deletion of the Y chromosome at the distal portion of band q11 was found in 6 men with normal male habitus but with azoospermia. Five of them were found during a survey of 1170 subfertile males while the sixth was karyotyped because of slight bone abnormalities. These findings, together with a review of the literature, suggest that on the distal portion of the nonfluorescent segment of the long arm of the Y, factors are located controlling spermatogenesis.read more
Citations
More filters
Journal ArticleDOI
A frequent Y chromosome b2/b3 subdeletion shows strong association with male infertility in Han-Chinese population
Bin Wu,N.X. Lu,Yankai Xia,Aihua Gu,Chuncheng Lu,Wei Wang,Lin Song,S.L. Wang,Hongbing Shen,Xinru Wang +9 more
TL;DR: The classical AZF deletions were the primary genetic factors for spermatogenic failure, while no significant association was found for AZFc subdeletions with sperm concentration, but the b2/b3 sub deletion was significantly associated with idiopathic male infertility, indicating a potential impairment of male fertility.
Journal ArticleDOI
A deletion map of the human Yq11 region: implications for the evolution of the Y chromosome and tentative mapping of a locus involved in spermatogenesis.
Barbara Bardoni,Orsetta Zuffardi,S Guioli,Andrea Ballabio,Paolo Simi,Pietro Cavalli,Maria Grazia Grimoldi,Marco Fraccaro,Giovanna Camerino +8 more
TL;DR: The correlation between the patient' phenotypes and the extent of their Yq11 deletions permits the tentative assignment of a locus involved in human spermatogenesis to a specific interval within Y Q11, suggesting the present organization of this region of the human Y chromosome is due to three physically and temporary distinct rearrangements.
Journal ArticleDOI
A human daz transgene confers partial rescue of the mouse dazl null phenotype
R. Slee,Brenda R. Grimes,R. M. Speed,Mary Taggart,S. M. Maguire,Andrew Ross,Niolette I. McGill,Philippa T. K. Saunders,Howard J. Cooke +8 more
TL;DR: Testing the capacity of a human DAZ gene contained in a 225-kb yeast artificial chromosome to complement the sterile phenotype of the Dazl null mouse (Dazl-/-) confirms the high degree of functional conservation between the DAZ and DAZL1 genes, suggesting they may constitute a single target for contraceptive intervention and raising the possibility of therapeutic up-regulation of the DAzL1 gene in infertile men.
Journal ArticleDOI
The Biology and Evolution of Mammalian Y Chromosomes.
Jennifer F. Hughes,David C. Page +1 more
TL;DR: In this paper, a third biological theme emerges from recent insights into the Y chromosome's roles beyond the reproductive tract, a theme that promises to broaden the reach of Y-chromosome research by shedding light on fundamental sex differences in human health and disease.
Journal ArticleDOI
The gr/gr deletion(s): a new genetic test in male infertility?
Claudia Giachini,E. Guarducci,Guy Longepied,Selene Degl’Innocenti,L. Becherini,Gianni Forti,Michael J. Mitchell,Csilla Krausz +7 more
TL;DR: Taking into consideration the Y chromosome structure and the suggested deletion mechanism, a number of other possible partial deletions have been proposed in both the AZFb and AZFc regions.
References
More filters
Journal ArticleDOI
A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities.
TL;DR: Data from a chromosome examination of 14,069 consecutive newborn infants is presented, finding 294 babies with a major chromosome abnormality or distinctive marker chromosomes.
Journal ArticleDOI
Possible role for H--Y antigen in the primary determination of sex.
TL;DR: The part that the X chromosome plays in male sexual differentiation has been clarified at the level of an individual gene situated on this chromosome.
Journal ArticleDOI
A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities
TL;DR: The results of the present study when combined with five other comparable studies, thus comprising a total of 46,150 newborn infants, indicates that the frequency of major chromosome abnormalities is between 1:150 and 1:200 live-born babies.
Journal ArticleDOI
Structural abnormalities of the Y chromosome in man.
Patricia A. Jacobs,A. Ross +1 more
Journal ArticleDOI
Chromosome polymorphism in a human newborn population. II. Potentials of polymorphic chromosome variants for characterizing the idiogram of an individual.
TL;DR: The baseline data presented here reinforce the view that polymorphic chromosome characteristics are very useful markers for characterizing the karyotype of an infant born at the Albert Einstein College Hospital, Bronx, New York, and are consistent with the expectations of the Hardy-Weinberg law.
Related Papers (5)
Human Y Chromosome Azoospermia Factors (AZF) Mapped to Different Subregions in Yq11
The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.
Helen Skaletsky,Tomoko Kuroda-Kawaguchi,Patrick Minx,Holland S. Cordum,LaDeana W. Hillier,Laura G. Brown,Sjoerd Repping,Tatyana Pyntikova,Johar Ali,Tamberlyn Bieri,Asif T. Chinwalla,Andrew Delehaunty,Kim D. Delehaunty,Hui Du,Ginger A. Fewell,Lucinda Fulton,Robert S. Fulton,Tina Graves,Shunfang Hou,Philip Latrielle,Shawn Leonard,Elaine R. Mardis,Rachel Maupin,John Douglas Mcpherson,Tracie L. Miner,William E. Nash,Christine Nguyen,Philip Ozersky,Kymberlie H. Pepin,Susan M. Rock,Tracy Rohlfing,Kelsi Scott,Brian Schultz,Cindy Strong,Aye Mon Tin-Wollam,Shiaw-Pyng Yang,Robert H. Waterston,Richard K. Wilson,Steve Rozen,David C. Page +39 more