Journal ArticleDOI
Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm.
TLDR
It is suggested that on the distal portion of the nonfluorescent segment of the long arm of the Y, factors are located controlling spermatogenesis.Abstract:
A deletion of the Y chromosome at the distal portion of band q11 was found in 6 men with normal male habitus but with azoospermia. Five of them were found during a survey of 1170 subfertile males while the sixth was karyotyped because of slight bone abnormalities. These findings, together with a review of the literature, suggest that on the distal portion of the nonfluorescent segment of the long arm of the Y, factors are located controlling spermatogenesis.read more
Citations
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Harnessing the full potential of reproductive genetics and epigenetics for male infertility in the era of “big data”
Darshan P. Patel,Timothy G. Jenkins,Timothy G. Jenkins,Kenneth I. Aston,Jingtao Guo,Jingtao Guo,Alexander W. Pastuszak,Heidi A. Hanson,James M. Hotaling +8 more
TL;DR: The current understanding of genetic and epigenetic causes of male infertility is reviewed and how findings may be translated into a practical component for the diagnosis and treatment of male fertility is reviewed.
Journal ArticleDOI
The role of the mouse y chromosome on susceptibility to testicular germ cell tumors.
TL;DR: This work uses chromosome substitution strains and a sex-reversing mutant to test the role of the Y chromosome on TGCT susceptibility and shows that a Y-linked gene that does not differ among the tested strains is essential for tumorigenesis.
Journal ArticleDOI
Prevalence of Azoospermia Factor (AZF) Deletions in Idiopathic Infertile Males in North-East India
TL;DR: Microdeletions of the Y-chromosome long arm are the most common mutations in infertile males, where they involve one or more "azoospermia factors" (AZF a, b, and c).
Journal ArticleDOI
Isolation of recombinant bacteriophage containing male-specific mouse DNA
TL;DR: Application of this screening procedure to a lambda library derived from mouse sperm DNA has yielded 12 distinct clones, part of whose sequences are present predominantly in male DNA.
References
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Journal ArticleDOI
A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities.
TL;DR: Data from a chromosome examination of 14,069 consecutive newborn infants is presented, finding 294 babies with a major chromosome abnormality or distinctive marker chromosomes.
Journal ArticleDOI
Possible role for H--Y antigen in the primary determination of sex.
TL;DR: The part that the X chromosome plays in male sexual differentiation has been clarified at the level of an individual gene situated on this chromosome.
Journal ArticleDOI
A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities
TL;DR: The results of the present study when combined with five other comparable studies, thus comprising a total of 46,150 newborn infants, indicates that the frequency of major chromosome abnormalities is between 1:150 and 1:200 live-born babies.
Journal ArticleDOI
Structural abnormalities of the Y chromosome in man.
Patricia A. Jacobs,A. Ross +1 more
Journal ArticleDOI
Chromosome polymorphism in a human newborn population. II. Potentials of polymorphic chromosome variants for characterizing the idiogram of an individual.
TL;DR: The baseline data presented here reinforce the view that polymorphic chromosome characteristics are very useful markers for characterizing the karyotype of an infant born at the Albert Einstein College Hospital, Bronx, New York, and are consistent with the expectations of the Hardy-Weinberg law.
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