Journal ArticleDOI
Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm.
TLDR
It is suggested that on the distal portion of the nonfluorescent segment of the long arm of the Y, factors are located controlling spermatogenesis.Abstract:
A deletion of the Y chromosome at the distal portion of band q11 was found in 6 men with normal male habitus but with azoospermia. Five of them were found during a survey of 1170 subfertile males while the sixth was karyotyped because of slight bone abnormalities. These findings, together with a review of the literature, suggest that on the distal portion of the nonfluorescent segment of the long arm of the Y, factors are located controlling spermatogenesis.read more
Citations
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Book ChapterDOI
Human Y Chromosome Function in Male Germ Cell Development
TL;DR: The chapter summarizes the present state of research and the ideas of possible AZF functional sites in the germ line, in which the expression of AZF genes may be involved, and the potential switch signals along the human germ cell differentiation pathway.
Journal ArticleDOI
Localization of a specific germ cell marker, DAZL1, in testicular germ cell neoplasias.
Beatriz Lifschitz-Mercer,David J. Elliott,Josephine Issakov,Leonor Leider-Trejo,Letizia Schreiber,Faina Misonzhnik,Avi Eisenthal,Batia Bar-Shira Maymon +7 more
TL;DR: The localization of a specific germ cell protein, DAZL1, in the putative ontogenic progenitor, I GCN, and in their putative derivative, seminoma, provides further support for the hypothesis that IGCN is the precursor of germ cell neoplasias.
Journal ArticleDOI
Analysis of Y chromosome microdeletion in 1738 infertile men from northeastern China.
TL;DR: In northeastern China, Y chromosome microdeletion diagnosis should be performed before the use of intracytoplasmic sperm injection in infertile men with sperm count ≤10 × 10(6)/mL, especially in men with azoospermia.
Journal ArticleDOI
Mice with Y chromosome deletion and reduced Rbm genes on a heterozygous Dazl1 null background mimic a human azoospermic factor phenotype
TL;DR: Reduction of Dazl1 and Rbm genes as well as/or deletion of the Y chromosome in mice gives rise to a phenotype similar to the heterogeneous AZFc phenotype observed in humans.
Journal ArticleDOI
The shorter zinc finger protein ZNF230 gene message is transcribed in fertile male testes and may be related to human spermatogenesis.
Sizhong Zhang,Weimin Qiu,Hui Wu,Ge Zhang,Mingkong Huang,Cuiying Xiao,Jun Yang,Christine Kamp,Xin-Li Huang,Karin Huellen,Ying Yue,Agen Pan,Roger V. Lebo,Aubrey Milunsky,Peter H. Vogt +14 more
TL;DR: The lack of detectable ZNF230 expression in azoospermic patients by reverse transcriptase-mediated PCR analysis is interpreted to mean that this gene is involved in maintaining normal human male fertility.
References
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Journal ArticleDOI
A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities.
TL;DR: Data from a chromosome examination of 14,069 consecutive newborn infants is presented, finding 294 babies with a major chromosome abnormality or distinctive marker chromosomes.
Journal ArticleDOI
Possible role for H--Y antigen in the primary determination of sex.
TL;DR: The part that the X chromosome plays in male sexual differentiation has been clarified at the level of an individual gene situated on this chromosome.
Journal ArticleDOI
A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities
TL;DR: The results of the present study when combined with five other comparable studies, thus comprising a total of 46,150 newborn infants, indicates that the frequency of major chromosome abnormalities is between 1:150 and 1:200 live-born babies.
Journal ArticleDOI
Structural abnormalities of the Y chromosome in man.
Patricia A. Jacobs,A. Ross +1 more
Journal ArticleDOI
Chromosome polymorphism in a human newborn population. II. Potentials of polymorphic chromosome variants for characterizing the idiogram of an individual.
TL;DR: The baseline data presented here reinforce the view that polymorphic chromosome characteristics are very useful markers for characterizing the karyotype of an infant born at the Albert Einstein College Hospital, Bronx, New York, and are consistent with the expectations of the Hardy-Weinberg law.
Related Papers (5)
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