Journal ArticleDOI
Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm.
TLDR
It is suggested that on the distal portion of the nonfluorescent segment of the long arm of the Y, factors are located controlling spermatogenesis.Abstract:
A deletion of the Y chromosome at the distal portion of band q11 was found in 6 men with normal male habitus but with azoospermia. Five of them were found during a survey of 1170 subfertile males while the sixth was karyotyped because of slight bone abnormalities. These findings, together with a review of the literature, suggest that on the distal portion of the nonfluorescent segment of the long arm of the Y, factors are located controlling spermatogenesis.read more
Citations
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Journal ArticleDOI
Cytogenetic and molecular analysis of infertile Chinese men: karyotypic abnormalities, Y-chromosome microdeletions, and CAG and GGN repeat polymorphisms in the androgen receptor gene.
TL;DR: The results confirmed the significant role of chromosome abnormalities, Y-chromosome microdeletions, and GGN repeats in Chinese male infertility.
Journal ArticleDOI
Genomic organization, physical mapping, and involvement in Yq microdeletions of the VCY2 (BPY 2) gene.
Liborio Stuppia,Valentina Gatta,Isabella Fogh,Anna Rita Gaspari,Elisena Morizio,Rita Mingarelli,Mariella Di Santo,Antonio Pizzuti,Giuseppe Calabrese,Giandomenico Palka +9 more
TL;DR: Analysis of the genomic structure demonstrated that the VCY2 gene is composed of 9 exons spanning 21 kb, and FISH analysis on interphase nuclei with specific probes for exons 4-6, 7, and 8 demonstrated the presence of a single gene copy, and Fiber-FISH on relaxed chromatin indicated thatVCY2 is located within the DAZ gene cluster.
Journal ArticleDOI
Y-chromosome microdeletions and male infertility.
TL;DR: Two candidate gene families, namely the RNA-binding motif-containing gene family and the deleted-in-azoospermia gene family, have been cloned by deletion mapping of infertile men with Y microdeletions and proposed as candidates for the putative azoospermia factor.
Journal ArticleDOI
The genetic basis of male infertility
TL;DR: The AZFor "azoospermia factor" locus was identified in this article using collections of deleted Y chromosomes to interval six of the long arm and it lies within cytological band Yq11.23.
Journal ArticleDOI
Y chromosome b2/b3 deletions and male infertility: A comprehensive meta-analysis, trial sequential analysis and systematic review
TL;DR: The Y-chromosome b2/b3 deletions increase infertility risk; however, it may be significant only in the Mongolian populations and the East Asian region.
References
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Journal ArticleDOI
A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities.
TL;DR: Data from a chromosome examination of 14,069 consecutive newborn infants is presented, finding 294 babies with a major chromosome abnormality or distinctive marker chromosomes.
Journal ArticleDOI
Possible role for H--Y antigen in the primary determination of sex.
TL;DR: The part that the X chromosome plays in male sexual differentiation has been clarified at the level of an individual gene situated on this chromosome.
Journal ArticleDOI
A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities
TL;DR: The results of the present study when combined with five other comparable studies, thus comprising a total of 46,150 newborn infants, indicates that the frequency of major chromosome abnormalities is between 1:150 and 1:200 live-born babies.
Journal ArticleDOI
Structural abnormalities of the Y chromosome in man.
Patricia A. Jacobs,A. Ross +1 more
Journal ArticleDOI
Chromosome polymorphism in a human newborn population. II. Potentials of polymorphic chromosome variants for characterizing the idiogram of an individual.
TL;DR: The baseline data presented here reinforce the view that polymorphic chromosome characteristics are very useful markers for characterizing the karyotype of an infant born at the Albert Einstein College Hospital, Bronx, New York, and are consistent with the expectations of the Hardy-Weinberg law.
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