Loss of microRNAs in pyramidal neurons leads to specific changes in inhibitory synaptic transmission in the prefrontal cortex
Ruby Hsu,Claude M. Schofield,Cassandra G. Dela Cruz,Dorothy M. Jones-Davis,Robert Blelloch,Erik M. Ullian +5 more
TLDR
A vital role for miRNAs in governing essential aspects of inhibitory transmission and interneuron development in the mammalian nervous system is suggested.About:
This article is published in Molecular and Cellular Neuroscience.The article was published on 2012-07-01 and is currently open access. It has received 51 citations till now. The article focuses on the topics: Interneuron & Prefrontal cortex.read more
Citations
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MicroRNAs Shape the Neuronal Landscape
TL;DR: Here it is considered that recent advances in the study of microRNA-mediated regulation of synaptic form and function in mice are considered to be significant.
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MeCP2 Suppresses Nuclear MicroRNA Processing and Dendritic Growth by Regulating the DGCR8/Drosha Complex
TL;DR: It is reported that MeCP2 regulates gene expression posttranscriptionally by suppressing nuclear microRNA processing by binding directly to DiGeorge syndrome critical region 8 (DGCR8), a critical component of the nuclear micro RNA-processing machinery, and interferes with the assembly of Drosha and DG CR8 complex.
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Expression of microRNAs and Other Small RNAs in Prefrontal Cortex in Schizophrenia, Bipolar Disorder and Depressed Subjects
TL;DR: There was a significant inverse correlation between the fold-change of a given miRNA seen in schizophrenia and its synaptic enrichment ratio observed in controls, suggesting some deficit in miRNA biogenesis, transport, processing or turnover in schizophrenia that is selective for the synaptic compartment.
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MicroRNAs and synaptic plasticity--a mutual relationship.
TL;DR: How neuronal activity influences each step in the lifetime of miRNAs, including the regulation of transcription, maturation, gene regulatory function and turnover in mammals is summarized.
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MicroRNA Profiling of Neurons Generated Using Induced Pluripotent Stem Cells Derived from Patients with Schizophrenia and Schizoaffective Disorder, and 22q11.2 Del
Dejian Zhao,Mingyan Lin,Jian Chen,Erika Pedrosa,Anastasia Hrabovsky,H. Matthew Fourcade,Deyou Zheng,Herbert M. Lachman +7 more
TL;DR: Differentially expressed miRNAs previously identified using autopsy samples and peripheral cells, both of which have significant methodological problems, are indeed disrupted in neuropsychiatric disorders and likely have an underlying genetic basis.
References
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Parvalbumin Expression in Visual Cortical Interneurons Depends on Neuronal Activity and TrkB Ligands during an Early Period of Postnatal Development
TL;DR: PARV expression depended on activity and TrkB ligands which appear to prime the PARV expression already before its developmental onset, suggesting that the development of class-specific morphological features is activity-independent.
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The GABAergic system in schizophrenia.
Brian Paul Blum,J. John Mann +1 more
TL;DR: Substantial evidence argues for a defect in the GABAergic system of the frontal cortex in schizophrenia which is limited to the parvalbumin-class of GABAergic interneurons.
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The synaptology of parvalbumin-immunoreactive neurons in the primate prefrontal cortex
TL;DR: A novel finding is that supragranular PV‐IR neurons exhibit dendritic patterns with predominantly vertical orientations, whereas infragranular cells exhibit mostly horizontal or oblique d endritic orientations.
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A role for noncanonical microRNAs in the mammalian brain revealed by phenotypic differences in Dgcr8 versus Dicer1 knockouts and small RNA sequencing
TL;DR: Deep sequencing of smallRNAs from the hippocampus and cortex of the conditional knockouts and control littermates identified multiple noncanonical microRNAs that were expressed at high levels in the brain relative to other tissues, including mirtrons and H/ACA snoRNA-derived small RNAs, and found no evidence for endo-siRNAs in thebrain.
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Noncanonical cytoplasmic processing of viral microRNAs.
TL;DR: It is demonstrated that incorporation of a primary miRNA into a cytoplasmic virus results in the formation of a Dicer-dependent, DGCR8-independent, mature miRNA capable of conferring RNAi-like activity, suggesting the existence of a noncanonical, small-RNA-based activity capable of processing cytopal hairpins and perhaps contributing to the cell's antiviral arsenal.