Loss of microRNAs in pyramidal neurons leads to specific changes in inhibitory synaptic transmission in the prefrontal cortex
Ruby Hsu,Claude M. Schofield,Cassandra G. Dela Cruz,Dorothy M. Jones-Davis,Robert Blelloch,Erik M. Ullian +5 more
TLDR
A vital role for miRNAs in governing essential aspects of inhibitory transmission and interneuron development in the mammalian nervous system is suggested.About:
This article is published in Molecular and Cellular Neuroscience.The article was published on 2012-07-01 and is currently open access. It has received 51 citations till now. The article focuses on the topics: Interneuron & Prefrontal cortex.read more
Citations
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MicroRNAs Shape the Neuronal Landscape
TL;DR: Here it is considered that recent advances in the study of microRNA-mediated regulation of synaptic form and function in mice are considered to be significant.
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MeCP2 Suppresses Nuclear MicroRNA Processing and Dendritic Growth by Regulating the DGCR8/Drosha Complex
TL;DR: It is reported that MeCP2 regulates gene expression posttranscriptionally by suppressing nuclear microRNA processing by binding directly to DiGeorge syndrome critical region 8 (DGCR8), a critical component of the nuclear micro RNA-processing machinery, and interferes with the assembly of Drosha and DG CR8 complex.
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Expression of microRNAs and Other Small RNAs in Prefrontal Cortex in Schizophrenia, Bipolar Disorder and Depressed Subjects
TL;DR: There was a significant inverse correlation between the fold-change of a given miRNA seen in schizophrenia and its synaptic enrichment ratio observed in controls, suggesting some deficit in miRNA biogenesis, transport, processing or turnover in schizophrenia that is selective for the synaptic compartment.
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MicroRNAs and synaptic plasticity--a mutual relationship.
TL;DR: How neuronal activity influences each step in the lifetime of miRNAs, including the regulation of transcription, maturation, gene regulatory function and turnover in mammals is summarized.
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MicroRNA Profiling of Neurons Generated Using Induced Pluripotent Stem Cells Derived from Patients with Schizophrenia and Schizoaffective Disorder, and 22q11.2 Del
Dejian Zhao,Mingyan Lin,Jian Chen,Erika Pedrosa,Anastasia Hrabovsky,H. Matthew Fourcade,Deyou Zheng,Herbert M. Lachman +7 more
TL;DR: Differentially expressed miRNAs previously identified using autopsy samples and peripheral cells, both of which have significant methodological problems, are indeed disrupted in neuropsychiatric disorders and likely have an underlying genetic basis.
References
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Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex
Claude M. Schofield,Ruby Hsu,Alison J. Barker,Caitlyn C. Gertz,Robert Blelloch,Erik M. Ullian +5 more
TL;DR: It is shown that Dgcr8+/- mice display reduced expression of a subset of microRNAs in the prefrontal cortex, a deficit that emerges over postnatal development that could represent endophenotypes of certain neuropsychiatric diseases of developmental onset.
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Specification of neuropeptide Y phenotype in visual cortical neurons by leukemia inhibitory factor.
TL;DR: This work analysed the specification of neurons expressing neuropeptide Y (NPY), a potent anticonvulsant, in organotypic visual cortex cultures, and found neurons that fail in this competition are parvalbuminergic basket and chandelier neurons, which express NPY transiently, but will not acquire a permanent NPY expression.
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Alterations of interneurons in the striatum and frontal cortex of mice during postnatal development.
TL;DR: The findings suggest that the expression of NGF in glia cells may play some role in the maturation of glial cells and PV‐positive interneurons in the striatum and frontal cortex during postnatal development.
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Vision: Dicer leaps into view
TL;DR: Report that geographic atrophy, a form of age-related blindness caused by cell death in the retinal pigmented epithelium, is associated with loss of activity of DICER1, a microRNA-processing enzyme, suggests a novel therapeutic target for an important cause of blindness.