Loss of microRNAs in pyramidal neurons leads to specific changes in inhibitory synaptic transmission in the prefrontal cortex
Ruby Hsu,Claude M. Schofield,Cassandra G. Dela Cruz,Dorothy M. Jones-Davis,Robert Blelloch,Erik M. Ullian +5 more
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TLDR
A vital role for miRNAs in governing essential aspects of inhibitory transmission and interneuron development in the mammalian nervous system is suggested.About:
This article is published in Molecular and Cellular Neuroscience.The article was published on 2012-07-01 and is currently open access. It has received 51 citations till now. The article focuses on the topics: Interneuron & Prefrontal cortex.read more
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MicroRNAs Shape the Neuronal Landscape
TL;DR: Here it is considered that recent advances in the study of microRNA-mediated regulation of synaptic form and function in mice are considered to be significant.
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MeCP2 Suppresses Nuclear MicroRNA Processing and Dendritic Growth by Regulating the DGCR8/Drosha Complex
TL;DR: It is reported that MeCP2 regulates gene expression posttranscriptionally by suppressing nuclear microRNA processing by binding directly to DiGeorge syndrome critical region 8 (DGCR8), a critical component of the nuclear micro RNA-processing machinery, and interferes with the assembly of Drosha and DG CR8 complex.
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Expression of microRNAs and Other Small RNAs in Prefrontal Cortex in Schizophrenia, Bipolar Disorder and Depressed Subjects
TL;DR: There was a significant inverse correlation between the fold-change of a given miRNA seen in schizophrenia and its synaptic enrichment ratio observed in controls, suggesting some deficit in miRNA biogenesis, transport, processing or turnover in schizophrenia that is selective for the synaptic compartment.
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MicroRNAs and synaptic plasticity--a mutual relationship.
TL;DR: How neuronal activity influences each step in the lifetime of miRNAs, including the regulation of transcription, maturation, gene regulatory function and turnover in mammals is summarized.
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MicroRNA Profiling of Neurons Generated Using Induced Pluripotent Stem Cells Derived from Patients with Schizophrenia and Schizoaffective Disorder, and 22q11.2 Del
Dejian Zhao,Mingyan Lin,Jian Chen,Erika Pedrosa,Anastasia Hrabovsky,H. Matthew Fourcade,Deyou Zheng,Herbert M. Lachman +7 more
TL;DR: Differentially expressed miRNAs previously identified using autopsy samples and peripheral cells, both of which have significant methodological problems, are indeed disrupted in neuropsychiatric disorders and likely have an underlying genetic basis.
References
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miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche
TL;DR: The SRY-box transcription factor Sox9 is identified as being a physiological target of miR-124 at the transition from the transit amplifying cell to the neuroblast stage, which is important for progression along the SVZ stem cell lineage to neurons.
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The origin and specification of cortical interneurons
TL;DR: Recent data that are beginning to illuminate the origins and specification of distinct subgroups of cortical interneurons are discussed.
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Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs
TL;DR: The results extend the known diversity of mammalian small RNA-generating pathways and show that mammalian siRNAs exist in cell types other than oocytes.
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Microarray analysis of microRNA expression in the developing mammalian brain
Eric A. Miska,Ezequiel Alvarez-Saavedra,Matthew Townsend,Matthew Townsend,Akira Yoshii,Nenad Sestan,Pasko Rakic,Martha Constantine-Paton,H. Robert Horvitz +8 more
TL;DR: A microarray technology that can be used to analyze the expression of microRNAs and of other small RNAs is described, suggesting that micro RNAs play important roles in the development of the mammalian brain.
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MicroRNA-mediated Feedback and Feedforward Loops are Recurrent Network Motifs in Mammals
TL;DR: This work develops a computational method that utilizes gene expression data to show that two classes of circuits-corresponding to positive and negative transcriptional coregulation of a miRNA and its targets-are prevalent in the human and mouse genomes.