MicroRNAs and ovarian function
Jason Baley,Julang Li +1 more
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TLDR
The current understanding of miRNA biogenesis, the role and mechanism that miRNAs play in post-transcriptional gene expression regulation, and specifically the current evidence of mi RNA involvement in ovarian development and function are reviewed.Abstract:
MicroRNAs (miRNAs) are a class of small non-coding RNAs which function in gene regulation with an important role in cell proliferation, maturation, and activity. The regulatory role of these small RNA molecules has recently begun to be explored in ovarian cells, uncovering their influence on gonadal development, steroidogenesis, apoptosis, ovulation, and corpus luteum development. This emerging area of research has extended and reshaped our understanding on how ovarian function is regulated. Here, we review the current understanding of miRNA biogenesis, the role and mechanism that miRNAs play in post-transcriptional gene expression regulation, and specifically the current evidence of miRNA involvement in ovarian development and function. Future comprehensive understanding of the role of miRNAs in the ovary in both physiological and pathological conditions may offer new treatment strategies for infertility and other ovarian disorders.read more
Citations
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Identification of suitable reference genes for miRNA quantitation in bumblebee (Hymenoptera: Apidae) response to reproduction
TL;DR: ThemiR-275 and miR-277 combination is identified to be the most reliable and suitable reference genes for the head and ovary of bumblebees.
Journal ArticleDOI
Non-coding RNA Expression Patterns of Two Different Teleost Gonad Maturation Stages.
TL;DR: This study demonstrates a gonad maturation biased ncRNA profile which in turn may support the role of ncRNAs in ovarian physiology and reproductive performance of fish, stressing the specific function of each RNA biotype in oocyte development.
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Genome -wide transcriptome profiling in ovaries of small-tail Han sheep during the follicular and luteal phases of the oestrous cycle.
TL;DR: A miRNA-regulated gene expression network was created for exploring the regulation of the follicular-luteal transition and quantitative real-time PCR verified the reliability of the RNA-seq data.
Journal ArticleDOI
Molecular characterization, tissue distribution, and expression of two ovarian Dicer isoforms during follicle development in goose (Anser cygnoides).
TL;DR: It is suggested that gDicer is required for follicle development, and structural differences in the helicase domain of two gDiter isoforms might contribute to their different roles in controlling granulosa cell apoptosis.
Journal ArticleDOI
The comprehensive mechanisms underlying nonhierarchical follicular development in geese (Anser cygnoides)
Hehe Liu,Wenjie Zhang,Qingqing Li,Junying Liu,Tao Zhang,Tianyu Zhou,Liang Li,Jiwen Wang,Hengyong Xu,Hua He +9 more
TL;DR: Gene Ontology and Kyoto Encyclopedia of Genes and Genome analyses showed that lipid metabolism, steroid secretion, extracellular ligand reactions, enzyme activities, the cell cycle, ECM-receptor interactions and the extrace cellular matrix are involved in follicular development.
References
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MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
TL;DR: In a four-genome analysis of 3' UTRs, approximately 13,000 regulatory relationships were detected above the estimate of false-positive predictions, thereby implicating as miRNA targets more than 5300 human genes, which represented 30% of the gene set.
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A microRNA expression signature of human solid tumors defines cancer gene targets
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Origins and Mechanisms of miRNAs and siRNAs
TL;DR: This work has revealed unexpected diversity in their biogenesis pathways and the regulatory mechanisms that they access, which has direct implications for fundamental biology as well as disease etiology and treatment.