MicroRNAs and ovarian function
Jason Baley,Julang Li +1 more
TLDR
The current understanding of miRNA biogenesis, the role and mechanism that miRNAs play in post-transcriptional gene expression regulation, and specifically the current evidence of mi RNA involvement in ovarian development and function are reviewed.Abstract:
MicroRNAs (miRNAs) are a class of small non-coding RNAs which function in gene regulation with an important role in cell proliferation, maturation, and activity. The regulatory role of these small RNA molecules has recently begun to be explored in ovarian cells, uncovering their influence on gonadal development, steroidogenesis, apoptosis, ovulation, and corpus luteum development. This emerging area of research has extended and reshaped our understanding on how ovarian function is regulated. Here, we review the current understanding of miRNA biogenesis, the role and mechanism that miRNAs play in post-transcriptional gene expression regulation, and specifically the current evidence of miRNA involvement in ovarian development and function. Future comprehensive understanding of the role of miRNAs in the ovary in both physiological and pathological conditions may offer new treatment strategies for infertility and other ovarian disorders.read more
Citations
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Journal ArticleDOI
Identification and profiling of microRNAs in the ovaries of polytocous and monotocous goats during estrus.
TL;DR: KEGG analysis showed that GnRH, transforming growth factor-beta, vascular endothelial growth factor, and mammalian target of rapamycin signaling pathways, oocyte meiosis and ovarian steroidogenesis participated in follicular development and ovulation.
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MicroRNAs control transcription factor NF-kB (p65) expression in human ovarian cells.
Alexander V. Sirotkin,Richard Alexa,Gabriela Kisova,Abdel Halim Harrath,Saleh Alwasel,Dmitriy Ovcharenko,Milos Mlyncek +6 more
TL;DR: This is the first direct demonstration that miRNAs affect NF-kB (p65) expression and the first genome-scale miRNA screen to identify upregulation and downregulation ofNF-kB accumulation by miRNas in the ovary.
Journal ArticleDOI
BDNF-induced expansion of cumulus-oocyte complexes in pigs was mediated by microRNA-205.
TL;DR: Evidence is provided that the BDNF-induced maturation of oocytes in pigs may be mediated by miR-205 through the regulation of potential target gene, ptx3, and the overexpression of miRNA-205 in granulosa cells and reporter gene assay shows that the marker gene p tx3 for cumulus expansion is the putative target gene of miR -205.
Journal ArticleDOI
High-Throughput Sequencing of Hair Follicle Development-Related Micrornas in Cashmere Goat at Various Fetal Periods
Yang Liu,Yang Liu,Lele Wang,Xiaoyan Li,Wenjing Han,Kun Yang,Honghao Wang,Yanjun Zhang,Rui Su,Zhihong Liu,Ruijun Wang,Zhiying Wang,Yanhong Zhao,Zhixin Wang,Jinquan Li +14 more
TL;DR: High-throughput sequencing of RNA samples from side skin of cashmere goat fetuses collected at three critical periods of skin hair follicle initiation, growth and development indicated that microRNAs in the oar-let-7 and oar -miR-200 families had been notably up-regulated relative to those in 45 days of pregnancy samples, which revealed that they might be the critical micro RNAs in hair follicles development.
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Identification of differentially expressed known and novel miRNAs in broodiness of goose.
Fang Chen,Jinjun Li,Hao Zhang,Jing Xu,Tao Zhengrong,Junda Shen,Shen Jianliang,Lizhi Lu,ChunMei Li +8 more
TL;DR: The study showed the expression of small RNAs in goose reproduction and identified known and novel miRNAs regulated in broodiness and reveals that these differentially expressed miRNAAs may be involved in broodness of A.cygnoides.
References
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MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
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Origins and Mechanisms of miRNAs and siRNAs
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