MicroRNAs and ovarian function
Jason Baley,Julang Li +1 more
TLDR
The current understanding of miRNA biogenesis, the role and mechanism that miRNAs play in post-transcriptional gene expression regulation, and specifically the current evidence of mi RNA involvement in ovarian development and function are reviewed.Abstract:
MicroRNAs (miRNAs) are a class of small non-coding RNAs which function in gene regulation with an important role in cell proliferation, maturation, and activity. The regulatory role of these small RNA molecules has recently begun to be explored in ovarian cells, uncovering their influence on gonadal development, steroidogenesis, apoptosis, ovulation, and corpus luteum development. This emerging area of research has extended and reshaped our understanding on how ovarian function is regulated. Here, we review the current understanding of miRNA biogenesis, the role and mechanism that miRNAs play in post-transcriptional gene expression regulation, and specifically the current evidence of miRNA involvement in ovarian development and function. Future comprehensive understanding of the role of miRNAs in the ovary in both physiological and pathological conditions may offer new treatment strategies for infertility and other ovarian disorders.read more
Citations
More filters
Journal ArticleDOI
Exosomal and Non-Exosomal Transport of Extra-Cellular microRNAs in Follicular Fluid: Implications for Bovine Oocyte Developmental Competence.
Md. Mahmodul Hasan Sohel,Michael Hoelker,Sina Seifi Noferesti,Dessie Salilew-Wondim,Ernst Tholen,Christian Looft,Franca Rings,Muhammad Jasim Uddin,Thomas E. Spencer,Karl Schellander,Dawit Tesfaye +10 more
TL;DR: The presence of exosome or non-exosome mediated transfer of miRNA in the bovine follicular fluid, and oocyte growth dependent variation in extra-cellular miRNA signatures in the follicular environment is demonstrated for the first time.
Journal ArticleDOI
Molecular characterization of exosomes and their microRNA cargo in human follicular fluid: bioinformatic analysis reveals that exosomal microRNAs control pathways involved in follicular maturation.
Manuela Santonocito,Marilena Vento,Maria Rosa Guglielmino,Rosalia Battaglia,Jessica Wahlgren,Marco Ragusa,Davide Barbagallo,Placido Borzì,Simona Rizzari,Marco Maugeri,Paolo Scollo,Carla Tatone,Hadi Valadi,Michele Purrello,Cinzia Di Pietro +14 more
TL;DR: This study identified a series of exosomal microRNAs that are highly represented in human FF and are involved in follicular maturation and could represent noninvasive biomarkers of oocyte quality in assisted reproductive technology.
Journal ArticleDOI
Characterization of serum microRNAs profile of PCOS and identification of novel non-invasive biomarkers.
TL;DR: Serum miRNAs are differentially expressed between PCOS patients and controls, and bioinformatics analysis indicated that the predicted targets function of the three miRN as mainly involved in the metastasis, cell cycle, apoptosis and endocrine.
Journal ArticleDOI
MicroRNA-133b stimulates ovarian estradiol synthesis by targeting Foxl2
Anyi Dai,Haixiang Sun,Ting Fang,Qun Zhang,Shaogen Wu,Yue Jiang,Lijun Ding,Guijun Yan,Yali Hu +8 more
TL;DR: It is demonstrated that miR‐133b down‐regulates Foxl2 expression in granulosa cells by directly targeting the 3′UTR, thus inhibiting the Foxl 2‐mediated transcriptional repression of StAR and CYP19A1 to promote estradiol production.
Journal ArticleDOI
MicroRNAs in ovarian function and disorders.
TL;DR: This review considers recent advances in the identification of miRNAs involved in the regulation of ovarian function as well as the possible influence ofmiRNAs on ovarian-derived disorders, such as ovarian cancer, polycystic ovarian syndrome and premature ovarian failure.
References
More filters
Journal ArticleDOI
Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs
TL;DR: The results extend the known diversity of mammalian small RNA-generating pathways and show that mammalian siRNAs exist in cell types other than oocytes.
Journal ArticleDOI
Mammalian mirtron genes.
TL;DR: The existence of well-conserved mammalian mirtrons indicates their relatively ancient incorporation into endogenous regulatory pathways, and it is hypothesized that different animals may have independently evolved the capacity for this hybrid small RNA pathway.
Journal ArticleDOI
Estrogen production and action
Linda R. Nelson,Serdar E. Bulun +1 more
TL;DR: There can be complex mechanisms that regulate the extraglandular production of estrogen in a tissue-specific and state-specific fashion, and local estrogen biosynthesis by aromatase activity in the brain may be important in the regulation of various cognitive and hypothalamic functions.
Journal ArticleDOI
Sequence requirements for micro RNA processing and function in human cells.
Yan Zeng,Bryan R. Cullen +1 more
TL;DR: The results suggest that miRNAs, and the closely similar small interfering RNAs, cannot totally discriminate between RNA targets differing by a single nucleotide.
Journal ArticleDOI
MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F
Géraldine Mathonnet,Marc R. Fabian,Yuri V. Svitkin,Armen Parsyan,Laurent Huck,Takayuki Murata,Stefano Biffo,William C. Merrick,Edward Darzynkiewicz,Ramesh S. Pillai,Witold Filipowicz,Thomas F. Duchaine,Nahum Sonenberg +12 more
TL;DR: It is shown here that translation initiation, specifically the 5′ cap recognition process, is repressed by endogenous let-7 miRNAs within the first 15 minutes of mRNA exposure to the extract when no destabilization of the transcript is observed.