MicroRNAs and ovarian function
Jason Baley,Julang Li +1 more
Reads0
Chats0
TLDR
The current understanding of miRNA biogenesis, the role and mechanism that miRNAs play in post-transcriptional gene expression regulation, and specifically the current evidence of mi RNA involvement in ovarian development and function are reviewed.Abstract:
MicroRNAs (miRNAs) are a class of small non-coding RNAs which function in gene regulation with an important role in cell proliferation, maturation, and activity. The regulatory role of these small RNA molecules has recently begun to be explored in ovarian cells, uncovering their influence on gonadal development, steroidogenesis, apoptosis, ovulation, and corpus luteum development. This emerging area of research has extended and reshaped our understanding on how ovarian function is regulated. Here, we review the current understanding of miRNA biogenesis, the role and mechanism that miRNAs play in post-transcriptional gene expression regulation, and specifically the current evidence of miRNA involvement in ovarian development and function. Future comprehensive understanding of the role of miRNAs in the ovary in both physiological and pathological conditions may offer new treatment strategies for infertility and other ovarian disorders.read more
Citations
More filters
Journal ArticleDOI
Exosomal and Non-Exosomal Transport of Extra-Cellular microRNAs in Follicular Fluid: Implications for Bovine Oocyte Developmental Competence.
Md. Mahmodul Hasan Sohel,Michael Hoelker,Sina Seifi Noferesti,Dessie Salilew-Wondim,Ernst Tholen,Christian Looft,Franca Rings,Muhammad Jasim Uddin,Thomas E. Spencer,Karl Schellander,Dawit Tesfaye +10 more
TL;DR: The presence of exosome or non-exosome mediated transfer of miRNA in the bovine follicular fluid, and oocyte growth dependent variation in extra-cellular miRNA signatures in the follicular environment is demonstrated for the first time.
Journal ArticleDOI
Molecular characterization of exosomes and their microRNA cargo in human follicular fluid: bioinformatic analysis reveals that exosomal microRNAs control pathways involved in follicular maturation.
Manuela Santonocito,Marilena Vento,Maria Rosa Guglielmino,Rosalia Battaglia,Jessica Wahlgren,Marco Ragusa,Davide Barbagallo,Placido Borzì,Simona Rizzari,Marco Maugeri,Paolo Scollo,Carla Tatone,Hadi Valadi,Michele Purrello,Cinzia Di Pietro +14 more
TL;DR: This study identified a series of exosomal microRNAs that are highly represented in human FF and are involved in follicular maturation and could represent noninvasive biomarkers of oocyte quality in assisted reproductive technology.
Journal ArticleDOI
Characterization of serum microRNAs profile of PCOS and identification of novel non-invasive biomarkers.
TL;DR: Serum miRNAs are differentially expressed between PCOS patients and controls, and bioinformatics analysis indicated that the predicted targets function of the three miRN as mainly involved in the metastasis, cell cycle, apoptosis and endocrine.
Journal ArticleDOI
MicroRNA-133b stimulates ovarian estradiol synthesis by targeting Foxl2
Anyi Dai,Haixiang Sun,Ting Fang,Qun Zhang,Shaogen Wu,Yue Jiang,Lijun Ding,Guijun Yan,Yali Hu +8 more
TL;DR: It is demonstrated that miR‐133b down‐regulates Foxl2 expression in granulosa cells by directly targeting the 3′UTR, thus inhibiting the Foxl 2‐mediated transcriptional repression of StAR and CYP19A1 to promote estradiol production.
Journal ArticleDOI
MicroRNAs in ovarian function and disorders.
TL;DR: This review considers recent advances in the identification of miRNAs involved in the regulation of ovarian function as well as the possible influence ofmiRNAs on ovarian-derived disorders, such as ovarian cancer, polycystic ovarian syndrome and premature ovarian failure.
References
More filters
Journal ArticleDOI
The role of microRNA in the delayed negative feedback regulation of gene expression
TL;DR: This communication incorporates miRNA into a previous mathematical model of gene expression with delayed negative feedback and demonstrates how this modified model can elucidate the possible effect of miRNA on the oscillatory gene expression.
Journal ArticleDOI
Molecular cloning and expression of bovine nucleoplasmin 2 (NPM2): a maternal effect gene regulated by miR-181a
TL;DR: It is suggested that expression of bovine NPM2 is temporally regulated during early embryogenesis and miR-181a may play a role in its regulation.
Journal ArticleDOI
Follicle-Stimulating Hormone-Responsive Cytoskeletal Genes in Rat Granulosa Cells: Class I β-Tubulin, Tropomyosin-4, and Kinesin Heavy Chain
TL;DR: FSH induces the massive reorganization of the cytoskeletons and morphological changes by the selective regulation of the gene expression, protein synthesis, and rearranged proteins in the ROG cells and probably, specific follicles and granulosa cells.
Journal Article
MicroRNA expression profiles in premature ovarian failure patients and its potential regulate functions
TL;DR: Some miRNAs expressed differently between POF patients and normal women, suggesting that they may be involved in the pathogensis of POF.
Journal ArticleDOI
The generation and characterization of an ovary-selective cDNA library.
TL;DR: Two novel ovary-specific/hormonally-dependent genes, the full-length sequences of which were isolated using RACE technology, may have significant implications for the understanding of ovarian function in molecular terms and for the development of innovative strategies for the promotion of fertility or its control.