MicroRNAs and ovarian function
Jason Baley,Julang Li +1 more
TLDR
The current understanding of miRNA biogenesis, the role and mechanism that miRNAs play in post-transcriptional gene expression regulation, and specifically the current evidence of mi RNA involvement in ovarian development and function are reviewed.Abstract:
MicroRNAs (miRNAs) are a class of small non-coding RNAs which function in gene regulation with an important role in cell proliferation, maturation, and activity. The regulatory role of these small RNA molecules has recently begun to be explored in ovarian cells, uncovering their influence on gonadal development, steroidogenesis, apoptosis, ovulation, and corpus luteum development. This emerging area of research has extended and reshaped our understanding on how ovarian function is regulated. Here, we review the current understanding of miRNA biogenesis, the role and mechanism that miRNAs play in post-transcriptional gene expression regulation, and specifically the current evidence of miRNA involvement in ovarian development and function. Future comprehensive understanding of the role of miRNAs in the ovary in both physiological and pathological conditions may offer new treatment strategies for infertility and other ovarian disorders.read more
Citations
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Journal ArticleDOI
miR-458b-5p regulates ovarian granulosa cells proliferation through Wnt/β-catenin signaling pathway by targeting catenin beta-1.
TL;DR: The data indicate that miR-458b-5p regulates ovarian GCs proliferation through Wnt/β-catenin signaling pathway by targeting CTNNB1, suggesting thatmiR- 458b- 5p and its target gene CTNNb1 may potentially play a role in chicken ovarian follicular development.
Journal ArticleDOI
The association of miR-25T>C, miR-32C>A, miR-125C>T, and miR-222G>T polymorphisms with a risk of primary ovarian insufficiency in Korean women.
Sung Hwan Cho,Young Ran Kim,Ji Hyang Kim,Hui Jeong An,Jung Oh Kim,Jung Jae Ko,Woo Sik Lee,Nam Keun Kim +7 more
TL;DR: Investigation of the association of microRNA polymorphisms with primary ovarian insufficiency (POI) in Korean women concluded that miR-25T>C,miR-32C>A, mi-125C>T, and mi-222G>T had no relation with POI.
Journal ArticleDOI
Role of miRNAs interference on ovarian functions and premature ovarian failure
Narjes Nouri,Olduz Shareghi-Oskoue,Leili Aghebati-Maleki,Shahla Danaii,Javad Ahmadian Heris,Mohammad Sadegh Soltani-Zangbar,Amin Kamrani,Mehdi Yousefi +7 more
TL;DR: In this article , the authors tried to talk over the mechanisms of miRNAs in regulating gene expression after transcription in the ovary, and investigated the regulating effects of small RNA molecules on steroidogenesis apoptosis, ovulation, gonadal, and corpus luteum development of ovaries.
Dissertation
Involvement of GDNF and microRNA-378 in the regulation of porcine follicle maturation
TL;DR: It is found that FSH mediates follicular differentiation by regulating expression of PGR, at least in part via the down regulation of miR-378, which has provided a deeper understanding of mechanisms involved in follicle maturation.
Dissertation
Role of cell-secreted vesicles in equine ovarian follicle development, The
da Silveira,Juliano Coelho +1 more
TL;DR: The next generation of smart phones will be able to recognise each other's voices, and provide real-time information about what the other is thinking and feeling about each other.
References
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MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Andrew Fire,SiQun Xu,Mary K. Montgomery,Steven A. Kostas,Steven A. Kostas,Samuel E. Driver,Craig C. Mello +6 more
TL;DR: To their surprise, it was found that double-stranded RNA was substantially more effective at producing interference than was either strand individually, arguing against stochiometric interference with endogenous mRNA and suggesting that there could be a catalytic or amplification component in the interference process.
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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
TL;DR: In a four-genome analysis of 3' UTRs, approximately 13,000 regulatory relationships were detected above the estimate of false-positive predictions, thereby implicating as miRNA targets more than 5300 human genes, which represented 30% of the gene set.
Journal ArticleDOI
A microRNA expression signature of human solid tumors defines cancer gene targets
Stefano Volinia,George A. Calin,Chang Gong Liu,Stefan Ambs,Amelia Cimmino,Fabio Petrocca,Rosa Visone,Marilena V. Iorio,Claudia Roldo,Manuela Ferracin,Robyn L. Prueitt,Nozumu Yanaihara,Giovanni Lanza,Aldo Scarpa,Andrea Vecchione,Massimo Negrini,Curtis C. Harris,Carlo M. Croce +17 more
TL;DR: The results indicate that miRNAs are extensively involved in cancer pathogenesis of solid tumors and support their function as either dominant or recessive cancer genes.
Journal ArticleDOI
Origins and Mechanisms of miRNAs and siRNAs
TL;DR: This work has revealed unexpected diversity in their biogenesis pathways and the regulatory mechanisms that they access, which has direct implications for fundamental biology as well as disease etiology and treatment.