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OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines

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TLDR
Twenty-five carefully worded recommendations have been generated based on a critical appraisal of existing guidelines, a systematic review of research evidence and the consensus opinions of an international, multidisciplinary group of experts for the management of hip and knee osteoarthritis.
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This article is published in Osteoarthritis and Cartilage.The article was published on 2008-02-01 and is currently open access. It has received 2616 citations till now. The article focuses on the topics: Evidence-based medicine & Critical appraisal.

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Cumulative knee adductor load distinguishes between healthy and osteoarthritic knees–A proof of principle study

TL;DR: Evidence of validity for cumulative knee adductor load is provided because non-normalization of the adduction moment impulse to magnitude or time emphasized the importance of the total loads borne through the medial knee compartment during each step.
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Comparison of three knee braces in the treatment of medial knee osteoarthritis.

TL;DR: No difference between the knee braces was found for pain reduction, discomfort or KAM, but the VER-brace was slightly more comfortable, which could ensure better compliance with treatment over the long term.
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Personalised Hip Therapy: development of a non-operative protocol to treat femoroacetabular impingement syndrome in the FASHIoN randomised controlled trial

TL;DR: Personalised Hip Therapy provides a structure for the non-operative care of FAI and offers guidance to clinicians and researchers in an evolving area with limited evidence.
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Osteoarthritis year 2012 in review: clinical.

TL;DR: A systematic literature review was conducted using PubMed for the period between September 1, 2011 and March 31, 2012 to focus on analytic and descriptive epidemiology and the role of both nonpharmacologic and pharmacologic therapies in the management of OA.
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Efficacy and Safety of the Selective Cyclooxygenase-2 Inhibitor Celecoxib in the Treatment of Rheumatoid Arthritis and Osteoarthritis in Japan

TL;DR: The analgesic activity of celecoxib, which was used for the treatment of RA, OA, and low back pain, was comparable to that of loxoprofen, and Celecoxib was safer in terms of GI injury often caused by other nonselective NSAIDs.
References
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Measuring inconsistency in meta-analyses

TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
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Bias in meta-analysis detected by a simple, graphical test

TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
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Assessing the quality of reports of randomized clinical trials : is blinding necessary?

TL;DR: An instrument to assess the quality of reports of randomized clinical trials (RCTs) in pain research is described and its use to determine the effect of rater blinding on the assessments of quality is described.
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Grading quality of evidence and strength of recommendations.

TL;DR: A system for grading the quality of evidence and the strength of recommendations that can be applied across a wide range of interventions and contexts is developed, and a summary of the approach from the perspective of a guideline user is presented.
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Primary, Secondary, and Meta-Analysis of Research

TL;DR: The meta-analysis of research as discussed by the authors is an important feature of the research and evaluation enterprise, and it has been widely used in the field of computer science and computer engineering, especially in the context of education.
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