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OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines

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TLDR
Twenty-five carefully worded recommendations have been generated based on a critical appraisal of existing guidelines, a systematic review of research evidence and the consensus opinions of an international, multidisciplinary group of experts for the management of hip and knee osteoarthritis.
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This article is published in Osteoarthritis and Cartilage.The article was published on 2008-02-01 and is currently open access. It has received 2616 citations till now. The article focuses on the topics: Evidence-based medicine & Critical appraisal.

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New horizons and perspectives in the treatment of osteoarthritis.

TL;DR: Current recommendations for the treatment of OA, the most recent evidence on the cardiovascular risks associated with current NSAID treatments, and the potential of newer anti-inflammatory agents with improved benefit-risk profiles are considered.
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Effect of Glucosamine on Pain-Related Disability in Patients With Chronic Low Back Pain and Degenerative Lumbar Osteoarthritis: A Randomized Controlled Trial

TL;DR: In this paper, the effect of glucosamine in patients with chronic low back pain (LBP) with degenerative lumbar osteoarthritis (OA) was investigated.
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Osteoarthritis patients' perceptions of “appropriateness” for total joint replacement surgery

TL;DR: Patients' pain experience was seen as most important in determining appropriateness, but felt to be inadequately evaluated currently, and enhanced patient-physician communication has potential to improve patient selection for TJA.
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Comorbid diseases as predictors of survival of primary total hip and knee replacements: a nationwide register-based study of 96 754 operations on patients with primary osteoarthritis

TL;DR: Comorbid diseases may play an important role in predicting survival of primary hip and knee replacements and their effect on cost-effectiveness of joint replacements, merit further research.
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Comparative, double-blind, controlled study of intra-articular hyaluronic acid (Hyalubrix ® ) injections versus local anesthetic in osteoarthritis of the hip

TL;DR: This comparative study suggests a beneficial effect and safety of intra-articular HA in the management of hip OA and significantly reduced Lequesne's algofunctional index 3 and 6 months after treatment.
References
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Measuring inconsistency in meta-analyses

TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
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Bias in meta-analysis detected by a simple, graphical test

TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
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Assessing the quality of reports of randomized clinical trials : is blinding necessary?

TL;DR: An instrument to assess the quality of reports of randomized clinical trials (RCTs) in pain research is described and its use to determine the effect of rater blinding on the assessments of quality is described.
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Grading quality of evidence and strength of recommendations.

TL;DR: A system for grading the quality of evidence and the strength of recommendations that can be applied across a wide range of interventions and contexts is developed, and a summary of the approach from the perspective of a guideline user is presented.
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Primary, Secondary, and Meta-Analysis of Research

TL;DR: The meta-analysis of research as discussed by the authors is an important feature of the research and evaluation enterprise, and it has been widely used in the field of computer science and computer engineering, especially in the context of education.
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