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OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines

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TLDR
Twenty-five carefully worded recommendations have been generated based on a critical appraisal of existing guidelines, a systematic review of research evidence and the consensus opinions of an international, multidisciplinary group of experts for the management of hip and knee osteoarthritis.
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This article is published in Osteoarthritis and Cartilage.The article was published on 2008-02-01 and is currently open access. It has received 2616 citations till now. The article focuses on the topics: Evidence-based medicine & Critical appraisal.

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A physiotherapist-delivered, combined exercise and pain coping skills training intervention for individuals with knee osteoarthritis: a pilot study.

TL;DR: The study showed that an intervention that combines exercise and PCST within the same treatment session and delivered by specially-trained physiotherapists is feasible and can improve both physical and psychological outcomes in individuals with knee OA.
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Soft tissue artifact compensation in knee kinematics by multi-body optimization: Performance of subject-specific knee joint models

TL;DR: This study shows that MBO can be improved with subject-specific knee joint models, and that the quality of the motion capture calibration is critical, as well as confirming that soft tissue artifact errors can be reduced in multi-body optimization.
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Comparison of the Reliability, Responsiveness, and Construct Validity of 4 Different Questionnaires for Evaluating Outcomes after Total Knee Arthroplasty

TL;DR: It was not possible to clearly identify a "best" or "better" tool and hence all can be considered useful, with the reported psychometric properties serving to guide the choice of instrument for a given purpose.
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Obesity and osteoarthritis: disease genesis and nonpharmacologic weight management.

TL;DR: The physiologic and mechanical consequences of obesity in older adults who have knee OA, the effects of long-term exercise and weight-loss interventions, the most effective nonpharmacologic treatments for obesity, and the usefulness and feasibility of translating these results to clinical practice are reviewed.
References
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Measuring inconsistency in meta-analyses

TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
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Bias in meta-analysis detected by a simple, graphical test

TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
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Assessing the quality of reports of randomized clinical trials : is blinding necessary?

TL;DR: An instrument to assess the quality of reports of randomized clinical trials (RCTs) in pain research is described and its use to determine the effect of rater blinding on the assessments of quality is described.
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Grading quality of evidence and strength of recommendations.

TL;DR: A system for grading the quality of evidence and the strength of recommendations that can be applied across a wide range of interventions and contexts is developed, and a summary of the approach from the perspective of a guideline user is presented.
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Primary, Secondary, and Meta-Analysis of Research

TL;DR: The meta-analysis of research as discussed by the authors is an important feature of the research and evaluation enterprise, and it has been widely used in the field of computer science and computer engineering, especially in the context of education.
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