OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines
Weiya Zhang,R W Moskowitz,George Nuki,S Abramson,R D Altman,Nigel K Arden,Sita M A Bierma-Zeinstra,K D Brandt,P Croft,Michael Doherty,Maxime Dougados,Marc C. Hochberg,David J. Hunter,K Kwoh,L S Lohmander,Peter Tugwell +15 more
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TLDR
Twenty-five carefully worded recommendations have been generated based on a critical appraisal of existing guidelines, a systematic review of research evidence and the consensus opinions of an international, multidisciplinary group of experts for the management of hip and knee osteoarthritis.About:
This article is published in Osteoarthritis and Cartilage.The article was published on 2008-02-01 and is currently open access. It has received 2616 citations till now. The article focuses on the topics: Evidence-based medicine & Critical appraisal.read more
Citations
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The “placebo” response in osteoarthritis and its implications for clinical practice
Michael Doherty,Paul Dieppe +1 more
TL;DR: A recent systematic review of randomised controlled trials in osteoarthritis has demonstrated that the effect size of "placebo" is substantial and is usually greater than that obtained from the specific effect of an individual treatment.
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Is Quadriceps Muscle Weakness a Risk Factor for Incident or Progressive Knee Osteoarthritis
Neil A. Segal,Natalie A. Glass +1 more
TL;DR: Information is summarized that greater quadriceps muscle strength is associated with a lower risk for progression of tibiofemoral joint space narrowing and cartilage loss in women.
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The effects of nonsteroidal anti-inflammatory drugs on clinical outcomes, synovial fluid cytokine concentration and signal transduction pathways in knee osteoarthritis. A randomized open label trial.
Luca Gallelli,Olimpio Galasso,Daniela Falcone,S. R. Southworth,Marta Greco,Valeria Ventura,Patrizia Romualdi,A. Corigliano,Rosa Terracciano,Rocco Savino,Elio Gulletta,Giorgio Gasparini,G. De Sarro +12 more
TL;DR: Short-term NSAID treatment improves the patient disease-specific quality of life with a parallel decrease in pro-inflammatory synovial fluid cytokine levels in knee OA.
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Intra-articular injection of photo-activated platelet-rich plasma in patients with knee osteoarthritis: a double-blind, randomized controlled pilot study.
TL;DR: This pilot study provides proof-of-concept evidence concerning the feasibility and safety of PA-PRP injections necessary to inform a larger clinical trial in people with knee OA and suggests photo-activated PRP may provide a safe and effective novel treatment for knees OA.
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Non-surgical treatments for the management of early osteoarthritis
Giuseppe Filardo,Elizaveta Kon,Umile Giuseppe Longo,Henning Madry,Paolo Marchettini,Antonio Marmotti,Dieter Van Assche,Giacomo Zanon,Giuseppe M. Peretti +8 more
TL;DR: Specific treatments aimed at improving joint homoeostasis, or even counteracting tissue damage by inducing regenerative processes, might be successful in early OA, where tissue loss and anatomical changes are still at very initial stages.
References
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