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OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines

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TLDR
Twenty-five carefully worded recommendations have been generated based on a critical appraisal of existing guidelines, a systematic review of research evidence and the consensus opinions of an international, multidisciplinary group of experts for the management of hip and knee osteoarthritis.
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This article is published in Osteoarthritis and Cartilage.The article was published on 2008-02-01 and is currently open access. It has received 2616 citations till now. The article focuses on the topics: Evidence-based medicine & Critical appraisal.

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Benefit-risk assessment of diacerein in the treatment of osteoarthritis.

TL;DR: Overall, there is evidence that diacerein is modestly effective for symptoms and possibly for radiographic changes, but this needs to be balanced against higher rates of gastrointestinal toxicity.
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The burden of OA-health services and economics

TL;DR: Osteoarthritis (OA) is a highly prevalent and disabling condition that affects over 7% of people globally (528 million people) and prevalence levels are even higher in countries with established market economies, which have older demographic profiles and a higher prevalence of obesity.
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Short-term use of nonsteroidal anti-inflammatory drugs and adverse effects: An updated systematic review

TL;DR: The use of NSAIDs may be considered relatively safe when prescribed at the most effective dose and for the shortest duration of time, which was defined to be 10 days or fewer.
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Lessons Learned from a Two-Round Delphi-based Scenario Study.

TL;DR: Practical details and lessons learned from a two-round Delphi-based scenario study in which projections (Delphi statements, questions or hypotheses) were developed with findings from expert interviews and an expert workshop are presented.
References
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Measuring inconsistency in meta-analyses

TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
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Bias in meta-analysis detected by a simple, graphical test

TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
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Assessing the quality of reports of randomized clinical trials : is blinding necessary?

TL;DR: An instrument to assess the quality of reports of randomized clinical trials (RCTs) in pain research is described and its use to determine the effect of rater blinding on the assessments of quality is described.
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Grading quality of evidence and strength of recommendations.

TL;DR: A system for grading the quality of evidence and the strength of recommendations that can be applied across a wide range of interventions and contexts is developed, and a summary of the approach from the perspective of a guideline user is presented.
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Primary, Secondary, and Meta-Analysis of Research

TL;DR: The meta-analysis of research as discussed by the authors is an important feature of the research and evaluation enterprise, and it has been widely used in the field of computer science and computer engineering, especially in the context of education.
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