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OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines

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TLDR
Twenty-five carefully worded recommendations have been generated based on a critical appraisal of existing guidelines, a systematic review of research evidence and the consensus opinions of an international, multidisciplinary group of experts for the management of hip and knee osteoarthritis.
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This article is published in Osteoarthritis and Cartilage.The article was published on 2008-02-01 and is currently open access. It has received 2616 citations till now. The article focuses on the topics: Evidence-based medicine & Critical appraisal.

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An overview of hydrogel-based intra-articular drug delivery for the treatment of osteoarthritis.

TL;DR: Hydrogel types and hydrogel characteristics for intra-articular injection, and the drugs, proteins and cells used in the injectable delivery systems are summarized to inspire researchers to construct novel hydrogels-based delivery system for the intra-artsicular injection treatment of knee OA.
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Application of robotic-assisted in situ 3D printing in cartilage regeneration with HAMA hydrogel: An in vivo study.

TL;DR: In this article, a six-degree-of-freedom (6-DOF) robot was introduced, and a fast tool center point (TCP) calibration method was developed to improve printing accuracy.
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Electro-Acupuncture is Beneficial for Knee Osteoarthritis: The Evidence from Meta-Analysis of Randomized Controlled Trials

TL;DR: Conclusively, the results indicate that EA is a great opportunity to remarkably alleviate the pain and improve the physical function of KOA patients with a low risk of adverse reaction.
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Intra-articular platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis

TL;DR: The intra-articular injection of PRP was not obviously superior to HA in knee OA, and similar results were observed for the function recovery according to the WOMAC function score and EuroQol-visual analog scales.
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Evaluation of the effect of glucosamine on an experimental rat osteoarthritis model.

TL;DR: GlcN has a potential to exert a chondroprotective action on OA by inhibiting type II collagen degradation and enhancingtype II collagen synthesis in the articular cartilage.
References
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Measuring inconsistency in meta-analyses

TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
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Bias in meta-analysis detected by a simple, graphical test

TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
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Assessing the quality of reports of randomized clinical trials : is blinding necessary?

TL;DR: An instrument to assess the quality of reports of randomized clinical trials (RCTs) in pain research is described and its use to determine the effect of rater blinding on the assessments of quality is described.
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Grading quality of evidence and strength of recommendations.

TL;DR: A system for grading the quality of evidence and the strength of recommendations that can be applied across a wide range of interventions and contexts is developed, and a summary of the approach from the perspective of a guideline user is presented.
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Primary, Secondary, and Meta-Analysis of Research

TL;DR: The meta-analysis of research as discussed by the authors is an important feature of the research and evaluation enterprise, and it has been widely used in the field of computer science and computer engineering, especially in the context of education.
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