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Open AccessJournal ArticleDOI

OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines

TLDR
Twenty-five carefully worded recommendations have been generated based on a critical appraisal of existing guidelines, a systematic review of research evidence and the consensus opinions of an international, multidisciplinary group of experts for the management of hip and knee osteoarthritis.
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This article is published in Osteoarthritis and Cartilage.The article was published on 2008-02-01 and is currently open access. It has received 2616 citations till now. The article focuses on the topics: Evidence-based medicine & Critical appraisal.

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Effect of glucosamine or chondroitin sulfate on the osteoarthritis progression: a meta-analysis.

TL;DR: This meta-analysis of available data shows that glucosamine and chondroitin sulfate may delay radiological progression of OA of the knee after daily administration for over 2 or 3 years.
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Pain Mechanisms in Osteoarthritis: Understanding the Role of Central Pain and Current Approaches to Its Treatment

TL;DR: The cascade of events from inflammation to activation of nociceptive and neuropathic pathways, to the development and maintenance of central and peripheral sensitization is surveyed, and preclinical and clinical evidence for the sensitization hypothesis is discussed.
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Relative efficacy of hyaluronic acid in comparison with NSAIDs for knee osteoarthritis: A systematic review and meta-analysis

TL;DR: It is suggested that IAHA might be a viable alternative to NSAIDs for knee OA, especially for older patients at greater risk for systemic adverse events, and given the favorable safety profile of IAHA over NSAIDs.
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Evidence for the efficacy of complementary and alternative medicines in the management of osteoarthritis: a systematic review

TL;DR: There was no consistent evidence available for any of the reviewed substances to suggest that they were efficacious as complementary medicines to standard treatment, and the available evidence does not support their current use in the management of RA.
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Muscle weakness in hip osteoarthritis: a systematic review.

TL;DR: Whether muscles of the affected legs of individuals with unilateral hip OA are weaker, smaller, and more inhibited than those of their contralateral leg and/or the legs of healthy controls is determined.
References
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Measuring inconsistency in meta-analyses

TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
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Bias in meta-analysis detected by a simple, graphical test

TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
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Assessing the quality of reports of randomized clinical trials : is blinding necessary?

TL;DR: An instrument to assess the quality of reports of randomized clinical trials (RCTs) in pain research is described and its use to determine the effect of rater blinding on the assessments of quality is described.
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Grading quality of evidence and strength of recommendations.

TL;DR: A system for grading the quality of evidence and the strength of recommendations that can be applied across a wide range of interventions and contexts is developed, and a summary of the approach from the perspective of a guideline user is presented.
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Primary, Secondary, and Meta-Analysis of Research

TL;DR: The meta-analysis of research as discussed by the authors is an important feature of the research and evaluation enterprise, and it has been widely used in the field of computer science and computer engineering, especially in the context of education.
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