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OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines

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TLDR
Twenty-five carefully worded recommendations have been generated based on a critical appraisal of existing guidelines, a systematic review of research evidence and the consensus opinions of an international, multidisciplinary group of experts for the management of hip and knee osteoarthritis.
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This article is published in Osteoarthritis and Cartilage.The article was published on 2008-02-01 and is currently open access. It has received 2616 citations till now. The article focuses on the topics: Evidence-based medicine & Critical appraisal.

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Statin Use and Clinical Osteoarthritis in the General Population: A Longitudinal Study

TL;DR: Higher therapeutic dose of statin, with a treatment duration of at least 2 years was associated with a significant reduction in clinical OA compared to non-statin users in the follow-up time period.
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Amorphous polyphosphate, a smart bioinspired nano-/bio-material for bone and cartilage regeneration: towards a new paradigm in tissue engineering

TL;DR: PolyP in combination with other, hydrogel-forming polymers provides the basis for the fabrication of hardenable bio-inks applicable in additive manufacturing/3D printing and 3D cell bioprinting of regeneratively active patient-specific osteo-articular implants.
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Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training

TL;DR: Serum COMP decreased significantly over the 12-week training period when treatment with glucosamines was added to the training regimen, suggesting an effect by glucosamine on the response of the OA cartilage to a period of joint loading in humans with knee OA.
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The rate of decline of joint space width in patients with osteoarthritis of the knee: a systematic review and meta-analysis of randomized placebo-controlled trials of chondroitin sulfate .

TL;DR: A meta-analysis of randomized double-blind placebo-controlled clinical trials demonstrated that chondroitin sulfate is effective for reducing the rate of decline in minimum joint space width in patients with OA of the knee.
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Adding Triamcinolone Improves Viscosupplementation: A Randomized Clinical Trial

TL;DR: The addition of triamcinolone hexacetonide improves first-week symptom and functional scores of viscosupplementation, but not beyond, and does not seem to increase the likelihood of adverse effects.
References
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Measuring inconsistency in meta-analyses

TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
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Bias in meta-analysis detected by a simple, graphical test

TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
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Assessing the quality of reports of randomized clinical trials : is blinding necessary?

TL;DR: An instrument to assess the quality of reports of randomized clinical trials (RCTs) in pain research is described and its use to determine the effect of rater blinding on the assessments of quality is described.
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Grading quality of evidence and strength of recommendations.

TL;DR: A system for grading the quality of evidence and the strength of recommendations that can be applied across a wide range of interventions and contexts is developed, and a summary of the approach from the perspective of a guideline user is presented.
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Primary, Secondary, and Meta-Analysis of Research

TL;DR: The meta-analysis of research as discussed by the authors is an important feature of the research and evaluation enterprise, and it has been widely used in the field of computer science and computer engineering, especially in the context of education.
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