OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines
Weiya Zhang,R W Moskowitz,George Nuki,S Abramson,R D Altman,Nigel K Arden,Sita M A Bierma-Zeinstra,K D Brandt,P Croft,Michael Doherty,Maxime Dougados,Marc C. Hochberg,David J. Hunter,K Kwoh,L S Lohmander,Peter Tugwell +15 more
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TLDR
Twenty-five carefully worded recommendations have been generated based on a critical appraisal of existing guidelines, a systematic review of research evidence and the consensus opinions of an international, multidisciplinary group of experts for the management of hip and knee osteoarthritis.About:
This article is published in Osteoarthritis and Cartilage.The article was published on 2008-02-01 and is currently open access. It has received 2616 citations till now. The article focuses on the topics: Evidence-based medicine & Critical appraisal.read more
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Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients.
Gianni Belcaro,Maria Rosaria Cesarone,Mark Dugall,Luciano Pellegrini,Andrea Ledda,M G Grossi,Stefano Togni,Giovanni Appendino +7 more
TL;DR: Significant improvements of both the clinical and biochemical end points were observed for Meriva compared to the control group, which suggests that Meriva is worth considering for the long-term complementary management of osteoarthritis.
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Dry needling: a literature review with implications for clinical practice guidelines.
TL;DR: The insertion of dry needles into asymptomatic body areas proximal and/or distal to the primary source of pain is supported by the myofascial pain syndrome literature, and physical therapists should not ignore the findings of the Western or biomedical ‘acupuncture’ literature.
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Strength training alone, exercise therapy alone, and exercise therapy with passive manual mobilisation each reduce pain and disability in people with knee osteoarthritis: a systematic review.
TL;DR: Exercise therapy plus manual mobilisation showed a moderate effect size on pain compared to the small effect sizes for strength training or exercise therapy alone, and physiotherapists or manual therapists might consider adding manual mobilisations to optimise supervised active exercise programs.
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Management of osteoarthritis of the knee
TL;DR: This review will outline evidence for management and emphasise the importance of a patient centred multidisciplinary approach, conservative non-drug interventions, judicious use of drugs, and appropriate surgical referral for osteoarthritis of the knee.
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Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway
TL;DR: Recent progress and challenges in the field in this highly competitive area of drug discovery are discussed and one of the first novel mechanisms of action for the treatment for pain for many years may be offered.
References
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