OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines
Weiya Zhang,R W Moskowitz,George Nuki,S Abramson,R D Altman,Nigel K Arden,Sita M A Bierma-Zeinstra,K D Brandt,P Croft,Michael Doherty,Maxime Dougados,Marc C. Hochberg,David J. Hunter,K Kwoh,L S Lohmander,Peter Tugwell +15 more
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TLDR
Twenty-five carefully worded recommendations have been generated based on a critical appraisal of existing guidelines, a systematic review of research evidence and the consensus opinions of an international, multidisciplinary group of experts for the management of hip and knee osteoarthritis.About:
This article is published in Osteoarthritis and Cartilage.The article was published on 2008-02-01 and is currently open access. It has received 2616 citations till now. The article focuses on the topics: Evidence-based medicine & Critical appraisal.read more
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Efficacy of Bletilla striata polysaccharide on hydrogen peroxide-induced apoptosis of osteoarthritic chondrocytes
Yen-Liang Lai,Yen-Liang Lai,Yu-Ying Lin,Yu-Ying Lin,S. Sadhasivam,Che-Yung Kuan,Che-Yung Kuan,Chih-Ying Chi,Chih-Ying Chi,Guo-Chung Dong,Feng-Huei Lin,Feng-Huei Lin +11 more
TL;DR: The outcome of this study has revealed that the down-regulation of catabolic gene expression by BSP treatment may open-up the development of new therapeutic approaches in OA.
Journal ArticleDOI
Methadone: an effective, safe drug of first choice for pain management in frail older adults.
TL;DR: Methadone is an excellent choice for pain in frail older adults and how adverse events can be minimized is demonstrated.
Journal ArticleDOI
A double-blind randomized placebo controlled study assessing safety, tolerability and efficacy of palmitoylethanolamide for symptoms of knee osteoarthritis
Elizabeth Steels,Elizabeth Steels,Ruchitha Venkatesh,Eleanor Steels,Gemma Vitetta,Luis Vitetta +5 more
TL;DR: It is demonstrated that palmitoylethanolamide may be a novel treatment for attenuating pain and reducing other associated symptoms of knee osteoarthritis.
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Prospective study on the effects of orthotic treatment for medial knee osteoarthritis in Chinese patients: clinical outcome and gait analysis.
TL;DR: These results support the use of orthotic treatment for early medial compartment knee osteoarthritis and indicate statistically significant reductions in peak and mean knee adduction moments in all orthotic groups when compared with a flat insole.
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Does exercise therapy improve the health-related quality of life of people with knee osteoarthritis? A systematic review and meta-analysis of randomized controlled trials
TL;DR: Exercise therapy can improve health-related QOL, as assessed by the SF-36, of knee osteoarthritis sufferers, and this meta-analysis provides high-quality evidence that exercise therapy increases the summary score, physical functioning score, and role-physical score of knee arthritis sufferers.
References
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Alejandro R. Jadad,R. A. Moore,Dawn Carroll,C. Jenkinson,David Reynolds,David J. Gavaghan,Henry J McQuay +6 more
TL;DR: An instrument to assess the quality of reports of randomized clinical trials (RCTs) in pain research is described and its use to determine the effect of rater blinding on the assessments of quality is described.
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Grading quality of evidence and strength of recommendations.
David C. Atkins,Dana Best,Peter A. Briss,Martin P Eccles,Yngve Falck-Ytter,Signe Flottorp,Gordon H. Guyatt,Robin Harbour,Margaret C Haugh,David Henry,Suzanne Hill,Roman Jaeschke,Gillian Leng,Alessandro Liberati,Nicola Magrini,James Mason,Philippa Middleton,Jacek Mrukowicz,Dianne L. O'Connell,Andrew D Oxman,Bob Phillips,Holger J. Schünemann,Tessa Tan-Torres Edejer,H. Varonen,Gunn Elisabeth Vist,John W Williams,Stephanie Zaza +26 more
TL;DR: A system for grading the quality of evidence and the strength of recommendations that can be applied across a wide range of interventions and contexts is developed, and a summary of the approach from the perspective of a guideline user is presented.
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