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Open AccessJournal ArticleDOI

OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines

TLDR
Twenty-five carefully worded recommendations have been generated based on a critical appraisal of existing guidelines, a systematic review of research evidence and the consensus opinions of an international, multidisciplinary group of experts for the management of hip and knee osteoarthritis.
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This article is published in Osteoarthritis and Cartilage.The article was published on 2008-02-01 and is currently open access. It has received 2616 citations till now. The article focuses on the topics: Evidence-based medicine & Critical appraisal.

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Ottawa panel evidence-based clinical practice guidelines for patient education programmes in the management of osteoarthritis

TL;DR: The Ottawa Panel recommendations are in concordances with other clinical practice guidelines related to the efficacy of patient education for the management of OA, especially to improve pain, physical activity level, self-efficacy and quality of life.
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The "MESACA" study: methylsulfonylmethane and boswellic acids in the treatment of gonarthrosis.

TL;DR: Although the combined administration of MSM and BA in the treatment of gonarthrosis was not shown to be more efficacious than placebo in the management of the clinical and functional picture, it significantly reduced patients need for anti-inflammatory drugs.
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The burden of musculoskeletal pain and the role of topical non-steroidal anti-inflammatory drugs (NSAIDs) in its treatment. Ten underpinning statements from a global pain faculty

TL;DR: The impact of musculoskeletal pain is described both in terms of the large numbers of sufferers and its economic impact and the evidence for the benefits and harms of topical NSAIDS including indicators of efficacy is presented.
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Nonoperative treatment of unicompartmental arthritis: from bracing to injection.

TL;DR: The use of conservative treatment of OA of the knee is reviewed, which includes unloader braces and viscosupplementation.
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Patterns of knee osteoarthritis in a hospital setting in sub-Saharan Africa.

TL;DR: Multiple factors including limited access to health care may account for why knee OA patients present at later stages of the disease with severe disability, and there was an association between pain and LDI.
References
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Measuring inconsistency in meta-analyses

TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
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Bias in meta-analysis detected by a simple, graphical test

TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
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Assessing the quality of reports of randomized clinical trials : is blinding necessary?

TL;DR: An instrument to assess the quality of reports of randomized clinical trials (RCTs) in pain research is described and its use to determine the effect of rater blinding on the assessments of quality is described.
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Grading quality of evidence and strength of recommendations.

TL;DR: A system for grading the quality of evidence and the strength of recommendations that can be applied across a wide range of interventions and contexts is developed, and a summary of the approach from the perspective of a guideline user is presented.
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Primary, Secondary, and Meta-Analysis of Research

TL;DR: The meta-analysis of research as discussed by the authors is an important feature of the research and evaluation enterprise, and it has been widely used in the field of computer science and computer engineering, especially in the context of education.
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