SARS-CoV-2: a storm is raging.
Savannah F. Pedersen,Ya Chi Ho +1 more
TLDR
Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design and the authors found that respiratory distress on admission is associated with unfavorable outcomes.Abstract:
The pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunological characteristics between moderate and severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10, and TNF-α), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFN-γ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design.read more
Citations
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Documenting the immune response in patients with COVID-19-induced acute respiratory distress syndrome
Junyu Lu,Xiaona Zeng,Weisheng Lu,Jihua Feng,Ye-Gui Yang,Yongxiang Wei,Yin Chen,Jianfeng Zhang,Liao Pinhu +8 more
TL;DR: In this paper , single-cell RNA sequencing data revealed significant phenotypic differences between patients with COVID-19-induced acute respiratory distress syndrome (ARDS) and controls, mainly in monocytes, and CD8+ T and B cells.
Journal ArticleDOI
Cell‐Based Biomaterials for Coronavirus Disease 2019 Prevention and Therapy
Chuyu Li,Hai-Yan Xie,Li-Li Huang +2 more
TL;DR: In this article , the characteristics and functions of cell-based biomaterials and their biological applications in COVID-19 prevention and therapy are described, and a look forward to the challenges of this aspect is presented.
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Traitements systémiques et risque infectieux dans le contexte de pandémie COVID-19
Journal ArticleDOI
Prise en charge des patients atteints de maladies rhumatismales pendant la pandémie de COVID-19: la Société française de rhumatologie répond aux questions fréquentes posées jusqu'en mai 2020.
Christophe Richez,René-Marc Flipo,Francis Berenbaum,Alain Cantagrel,Pascal Claudepierre,Françoise Debiais,Philippe Dieudé,Philippe Goupille,Christian Roux,Thierry Schaeverbeke,Daniel Wendling,Thao Pham,Thierry Thomas +12 more
TL;DR: In this article, les rhumatologues doivent composer avec the pandemie of COVID-19dans la prise en charge de leurs patients, ce qui a souleve de nombreuses interrogations sur l’utilisation des anti-inflammatoires and des traitements de fond antirhumatismaux (DMARD).
Journal ArticleDOI
Pathophysiologie von COVID-19 und deren mögliche Bedeutung für Long-COVID
Johannes Scherr,Johannes Scherr +1 more
TL;DR: In this paper, a review of the results of klinischen Veranderungen dargestellt werden is presented, in dem vorliegenden Review sollen die zugrundeliegenden Pathophysiologien/-mechanismen sowie die relevantesten hieraus resultierenden klinical-Veranderungensdargestellert wererden.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
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Clinical Characteristics of Coronavirus Disease 2019 in China.
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.
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Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia.
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TL;DR: There is evidence that human-to-human transmission has occurred among close contacts since the middle of December 2019 and considerable efforts to reduce transmission will be required to control outbreaks if similar dynamics apply elsewhere.
Journal ArticleDOI
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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