SARS-CoV-2: a storm is raging.
Savannah F. Pedersen,Ya Chi Ho +1 more
TLDR
Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design and the authors found that respiratory distress on admission is associated with unfavorable outcomes.Abstract:
The pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunological characteristics between moderate and severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10, and TNF-α), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFN-γ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design.read more
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Pregnancy-specific responses to COVID-19 are revealed by high-throughput proteomics of human plasma
TL;DR: In this paper , a comprehensive characterization of the plasma proteome of pregnant and non-pregnant COVID-19 patients and controls was presented, and shared and pregnancy-specific proteomic changes were identified: pregnant women display a tailored response that may protect the conceptus from heightened inflammation, while nonsmokers display a stronger response to repel infection.
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Dexamethasone in Treatment of Comorbid SARS-CoV-2 Patients Aged over 50 Years with Lung Injury over 50 %
О. Ю. Зольникова,Р. В. Масленников,В. Т. Ивашкин,Н. Л. Джахая,О. Ю. Киселева,Н. Д. Поцхверашвили,С. А. Шорохова +6 more
TL;DR: In this paper, a retrospective study of 158 SARS-CoV-2 patients hospitalised in April-June 2020 was conducted under the inclusion criteria: age over 50 years, chest computed tomography (CT) for COVID-19-associated pneumonia, C-reactive protein (CRP) >50 mg/L, anticoagulant therapy, no contraindications to steroids, no biologic therapy.
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Dissecting the Interrelationship between COVID-19 and Diabetes Mellitus.
Pratiksha H Roham,Shilpy Sharma +1 more
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Oral Health Condition in COVID-19
TL;DR: Amaç et al. as mentioned in this paper reported COVID-19 olan hastaların toplam ağız sağlığı skor değerleri, kontrol grubuna göre olumlu yönde daha yüksekti (p=0,011).
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Post-mortem findings in Spanish patients with COVID-19; a special focus on superinfections
Inmaculada Ruiz-Caceres,T. Hermida Romero,I. Guerra Merino,J. Portu Zapirain,Belén Pérez-Mies,Matilde Sánchez-Conde,Marina Alonso Riaño,Rafael Rubio,José Fortes Alen,Á. Vidal González,Clara Salas Antón,Elena Múñez,Sánchez Sánchez R,D. Corona-Mata,I. Aldecoa Ansorregui,José M. Miró,Raquel Beloqui Perez de Obanos,Carlos Ibero,Javier Gómez-Román,M. Carmen Fariñas,Enrique de Alava,José Miguel Cisneros,Xavier Matias-Guiu,Antonio Rivero +23 more
TL;DR: In this article , the authors analyzed pathological findings in a large series of full-body autopsies, with a special focus on super-infections, and confirmed the main necropsy histopathological findings attributed to coronavirus disease 2019 (COVID-19).
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
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Clinical Characteristics of Coronavirus Disease 2019 in China.
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TL;DR: During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness, and patients often presented without fever, and many did not have abnormal radiologic findings.
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.
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Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia.
Qun Li,Xuhua Guan,Peng Wu,Xiaoye Wang,Lei Zhou,Yeqing Tong,Ruiqi Ren,Kathy Leung,Eric H. Y. Lau,Jessica Y. Wong,Xuesen Xing,Nijuan Xiang,Yang Wu,Chao Li,Chen Qi,Dan Li,Tian Liu,Jing Zhao,Man Liu,Wenxiao Tu,Chuding Chen,Lianmei Jin,Rui Yang,Qi Wang,Suhua Zhou,Rui Wang,Hui Liu,Yingbo Luo,Yuan Liu,Ge Shao,Huan Li,Zhongfa Tao,Yang Yang,Yang Yang,Zhiqiang Deng,Boxi Liu,Zhitao Ma,Yanping Zhang,Guoqing Shi,Tommy Tsan-Yuk Lam,Joseph T. Wu,George F. Gao,George F. Gao,Benjamin J. Cowling,Bo Yang,Gabriel M. Leung,Zijian Feng +46 more
TL;DR: There is evidence that human-to-human transmission has occurred among close contacts since the middle of December 2019 and considerable efforts to reduce transmission will be required to control outbreaks if similar dynamics apply elsewhere.
Journal ArticleDOI
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
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