SARS-CoV-2: a storm is raging.
Savannah F. Pedersen,Ya Chi Ho +1 more
TLDR
Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design and the authors found that respiratory distress on admission is associated with unfavorable outcomes.Abstract:
The pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunological characteristics between moderate and severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10, and TNF-α), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFN-γ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design.read more
Citations
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COVID-19 mortality risk factors in older people in a long-term care center
Eva Heras,Pablo Garibaldi,Maite Boix,Oliver Valero,Jorge Castillo,Yurisan Curbelo,Elso Gonzalez,Obilagilio Mendoza,Maria Anglada,Joan Carles Miralles,Petra Llull,Ricard Llovera,Josep M. Piqué +12 more
TL;DR: The independent prognostic factors identified in the present study can help to adjust the healthcare resources in this population in case of new outbreaks of the COVID-19 pandemic.
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Managing Cutaneous Immune-Mediated Diseases During the COVID-19 Pandemic.
Tiago Torres,Luis Puig +1 more
TL;DR: Cutaneous immune-mediated diseases, including psoriasis, atopic dermatitis, and hidradenitis suppurativa, are therapeutically managed with biologic and non-biologic immunosuppressive and immunomodulatory drugs during the COVID-19 pandemic.
Posted ContentDOI
Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium
Neal G. Ravindra,Mia Madel Alfajaro,Victor Gasque,Victoria Habet,Jin Wei,Renata B. Filler,Nicholas C. Huston,Han Wan,Klara Szigeti-Buck,Bao Wang,Guilin Wang,Ruth R. Montgomery,Stephanie C. Eisenbarth,Adam Williams,Anna Marie Pyle,Anna Marie Pyle,Akiko Iwasaki,Akiko Iwasaki,Tamas L. Horvath,Ellen F. Foxman,Richard W. Pierce,David van Dijk,Craig B. Wilen +22 more
TL;DR: In this paper, the authors performed single-cell RNA sequencing of experimentally infected human bronchial epithelial cells (HBECs) in air-liquid interface cultures over a time-course.
Journal ArticleDOI
COVID-19, Virology and Geroscience: A Perspective.
Camille Vellas,Camille Vellas,Pierre Delobel,Pierre Delobel,P. de Souto Barreto,Jacques Izopet,Jacques Izopet +6 more
TL;DR: This Perspective paper discusses about the possibility that the so-called “immunosenescence” and “inflammaging” processes, already present in a fraction of frail older adults, could allow the immune escape of SARS-CoV-2 leading to COVID-19 serious complications.
Journal ArticleDOI
Neurological consequences of COVID-19: what have we learned and where do we go from here?
Abbas Jarrahi,Meenakshi Ahluwalia,Hesam Khodadadi,Évila Lopes Salles,Ravindra Kolhe,David C. Hess,Fernando L. Vale,Manish Kumar,Babak Baban,Kumar Vaibhav,Krishnan M. Dhandapani +10 more
TL;DR: The current body of literature regarding the central nervous system (CNS) effects of SARS-CoV-2 is summarized and several potential targets for therapeutic development to reduce neurological consequences in COVID-19 patients are discussed.
References
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Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia.
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TL;DR: There is evidence that human-to-human transmission has occurred among close contacts since the middle of December 2019 and considerable efforts to reduce transmission will be required to control outbreaks if similar dynamics apply elsewhere.
Journal ArticleDOI
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
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