SARS-CoV-2: a storm is raging.
Savannah F. Pedersen,Ya Chi Ho +1 more
TLDR
Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design and the authors found that respiratory distress on admission is associated with unfavorable outcomes.Abstract:
The pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunological characteristics between moderate and severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10, and TNF-α), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFN-γ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design.read more
Citations
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COVID-19 associated thromboinflammation of renal capillary: potential mechanisms and treatment
Xiaojing Chen,Chengyuan Yu,Haijiao Jing,Chunxu Wang,Xinyi Zhao,Jinming Zhang,Shuoqi Zhang,Huan Liu,Rujuan Xie,Jialan Shi,Jialan Shi +10 more
TL;DR: In this article, the effects of pathophysiological mechanisms such as inflammatory storm, endothelial injury, phosphatidylserine expression, extracellular traps release on renal capillary thrombosis caused by COVID-19 infection are discussed.
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Thymidine Phosphorylase Is Increased in COVID-19 Patients in an Acuity-Dependent Manner
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On the role of bacterial metalloproteases in COVID-19 associated cytokine storm.
TL;DR: In this article, the authors hypothesize that bacteria promoting shedding and increase the sIL-6R level can be an important contributing factor for the development of cytokine storms, and support the consideration of the prophylactic use of antibiotics more widely and at an earlier stage of infection.
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Pacritinib Inhibition of IRAK1 Blocks Aberrant TLR8 Signalling by SARS-CoV-2 and HIV-1-Derived RNA.
TL;DR: It is demonstrated that pacritinib inhibits the TLR8-dependent pro-inflammatory cytokine response elicited by GU-rich single-stranded RNA derived from SARS-CoV-2 and HIV-1.
References
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TL;DR: There is evidence that human-to-human transmission has occurred among close contacts since the middle of December 2019 and considerable efforts to reduce transmission will be required to control outbreaks if similar dynamics apply elsewhere.
Journal ArticleDOI
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
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