SARS-CoV-2: a storm is raging.
Savannah F. Pedersen,Ya Chi Ho +1 more
TLDR
Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design and the authors found that respiratory distress on admission is associated with unfavorable outcomes.Abstract:
The pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunological characteristics between moderate and severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10, and TNF-α), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFN-γ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design.read more
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Herd-immunity against COVID-19: Is it enough to stop a second wave?
Mohamed AbdAllah,Ahmed Cordie +1 more
TL;DR: Many reports doubt the efficacy and durability of the “post-infection” immunity, therefore, countries should not rely on herd-immunity for protection against the further-coming wave of COVID-19.
Journal ArticleDOI
Pregnancy-specific responses to COVID-19 are revealed by high-throughput proteomics of human plasma
Nardhy Gomez-Lopez,Roberto Romero,Maria Cabrera Escobar,J. Carvajal,María Paula Echavarría,Ludwig L Albornoz,Daniela Nasner,Derek Miller,Dahiana Gallo,Jose Galaz,Marcia Arenas-Hernandez,Gaurav Bhatti,Bogdan Done,M. Zambrano,Isabella Ramos,Paula Andrea Fernández,Leandro Posada,Tinnakorn Chaiworapongsa,Eun Jung Jung,Valeria Garcia-Flores,Manaphat Suksai,Francesca Gotsch,Maria Camila Bandeira Seixas Bosco,Nandor Gabor Than,Adi L. Tarca +24 more
TL;DR: In this paper , a comprehensive characterization of the plasma proteome of pregnant and non-pregnant COVID-19 patients was performed using the SOMAmer platform, which revealed that pregnant women display a tailored response that may protect the conceptus from heightened inflammation, while non-Pregnant individuals display a stronger response to repel infection.
Journal ArticleDOI
Update on treatment and preventive interventions against COVID-19: an overview of potential pharmacological agents and vaccines.
Yinan Xiao,Hanyue Xu,Wen Guo,Yunuo Zhao,Yuling Luo,Ming Wang,Zhiyao He,Zhenyu Ding,Ji-Yan Liu,Lei Deng,Fushen Sha,Xuelei Ma +11 more
TL;DR: This review mainly focused on promising candidates for the treatment of COVID-19 and collected recently updated evidence relevant to its feasibility in clinical practice in the near future.
Journal ArticleDOI
Infekcija SARS-CoV-2 (COVID-19) u djece
TL;DR: A pandemija uzrokovana SARS-om -CoV-2 veliki je javnozdravstveni problem u svim zemljama svijeta as discussed by the authors.
Journal ArticleDOI
TRPC3-Nox2 Protein Complex Formation Increases the Risk of SARS-CoV-2 Spike Protein-Induced Cardiomyocyte Dysfunction through ACE2 Upregulation
Yuri Kato,Kazuhiro Nishiyama,Jae Man Lee,Yuko Ibuki,Yumiko Imai,Takamasa Noda,Noriho Kamiya,Takehiro Kusakabe,Yasunari Kanda,Motohiro Nishida +9 more
TL;DR: In this paper , ibudilast, which was previously identified as a potent inhibitor of protein complex between transient receptor potential canonical (TRPC) 3 and NADPH oxidase (Nox) 2, attenuates the SARS-CoV-2 spike glycoprotein pseudovirus-evoked contractile and metabolic dysfunctions of neonatal rat cardiomyocytes (NRCMs).
References
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Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia.
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TL;DR: There is evidence that human-to-human transmission has occurred among close contacts since the middle of December 2019 and considerable efforts to reduce transmission will be required to control outbreaks if similar dynamics apply elsewhere.
Journal ArticleDOI
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
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