SARS-CoV-2: a storm is raging.
Savannah F. Pedersen,Ya Chi Ho +1 more
TLDR
Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design and the authors found that respiratory distress on admission is associated with unfavorable outcomes.Abstract:
The pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunological characteristics between moderate and severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10, and TNF-α), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFN-γ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design.read more
Citations
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Cytokine Storm in Coronavirus Disease 2019 and Adult-Onset Still's Disease: Similarities and Differences.
Jianfen Meng,Yuning Ma,Jinchao Jia,Mengyan Wang,Jialin Teng,Hui Shi,Honglei Liu,Yutong Su,Junna Ye,Yue Sun,Xiaobing Cheng,Huihui Chi,Tingting Liu,Dehao Zhu,Zhuochao Zhou,Liyan Wan,Zhihong Wang,Fan Wang,Xin Qiao,Xia Chen,Hao Zhang,Zihan Tang,Chengde Yang,Qiongyi Hu +23 more
TL;DR: In this article, a literature search was performed using the databases PubMed, EMBASE, and Web of Science to collect the levels of cytokine including IL-1β, IL-6 and IL-10 in severe COVID-19 patients.
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Signaling pathways in the regulation of cytokine release syndrome in human diseases and intervention therapy.
TL;DR: In this article, the authors have summarized the most recent advances related to the clinical features and management of CRS as well as cutting-edge technologies to elucidate the mechanisms of the CRS.
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Ozone therapy for the treatment of COVID-19 pneumonia: A scoping review.
Morteza Izadi,Luca Cegolon,Mohammad Javanbakht,Ali Sarafzadeh,Hassan Abolghasemi,Gholam Hossein Alishiri,Shi Zhao,Behzad Einollahi,Mandana Kashaki,Nematollah Jonaidi-Jafari,Mosa Asadi,Ramezan Jafari,Saeid Fathi,Hassan Nikoueinejad,Mehrdad Ebrahimi,Sina Imanizadeh,Amir Hosein Ghazale +16 more
TL;DR: In this article, ozone therapy is recommended to counter the disruptive effects of severe COVID-19 on lung tissues, especially if administered in early stages of the disease, thereby preventing the progression to ARDS.
Journal ArticleDOI
Highlights in the fight against COVID-19: does autophagy play a role in SARS-CoV-2 infection?
TL;DR: Recent developments in the effort to combat COVID-19 are presented and whether SARS-CoV-2 may potentially interact with the host autophagy pathway is considered.
Journal ArticleDOI
Inflammatory profiles and clinical features of COVID-19 survivors three months after discharge in Wuhan, China.
Mei Zhou,Zhengrong Yin,Juanjuan Xu,Sufei Wang,Tingting Liao,Kai Wang,Yumei Li,Fan Yang,Zhen Wang,Guanghai Yang,Jian-Chu Zhang,Jin Yang +11 more
TL;DR: Wang et al. as discussed by the authors explored the inflammatory profiles and clinical recovery of COVID-19 patients at 3 months post-discharge and found that levels of immune cells had returned to nearly normal levels and were not significantly correlated with abnormal clinical features.
References
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TL;DR: There is evidence that human-to-human transmission has occurred among close contacts since the middle of December 2019 and considerable efforts to reduce transmission will be required to control outbreaks if similar dynamics apply elsewhere.
Journal ArticleDOI
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
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