SARS-CoV-2: a storm is raging.
Savannah F. Pedersen,Ya Chi Ho +1 more
TLDR
Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design and the authors found that respiratory distress on admission is associated with unfavorable outcomes.Abstract:
The pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunological characteristics between moderate and severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10, and TNF-α), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFN-γ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design.read more
Citations
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Prognostic parameters of in-hospital mortality in COVID-19 patients-An Italian experience.
Massimiliano Ruscica,Chiara Macchi,Simona Iodice,Gregorio Tersalvi,Irene Rota,Simone Ghidini,Leonardo Terranova,Luca Valenti,Luca Valenti,Francesco Amati,Stefano Aliberti,Stefano Aliberti,Alberto Corsini,Francesco Blasi,Francesco Blasi,Stefano Carugo,Stefano Carugo,Valentina Bollati,Marco Vicenzi,Marco Vicenzi +19 more
TL;DR: In this paper, the authors used multivariate Cox regression analysis to test a large spectrum of variables ranging from clinical evaluation to laboratory biomarkers to identify which parameter would best predict all-cause in-hospital mortality in COVID-19 patients.
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Efficacy of Early Combination Therapy With Lianhuaqingwen and Arbidol in Moderate and Severe COVID-19 Patients: A Retrospective Cohort Study
Jie Fang,Hui Li,Wei Du,Ping Yu,Ying-Yun Guan,Shi-Yu Ma,Dong Liu,Wei Chen,Guochao Shi,Xiao-Lan Bian +9 more
TL;DR: The early combined usage of LHQW and Arbidol may accelerate recovery and improve the prognosis of patients with moderate COVID-19.
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Sphingolipids as Modulators of SARS-CoV-2 Infection
Kid Törnquist,Kid Törnquist,Muhammad Yasir Asghar,Vignesh Srinivasan,Vignesh Srinivasan,Laura Korhonen,Dan Lindholm,Dan Lindholm +7 more
TL;DR: In this article, the authors reviewed recent findings regarding sphingolipids in the uptake of SARS-CoV-2 and in the course of COVID-19 disease.
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Clinical characterization and risk factors associated with cytokine release syndrome induced by COVID-19 and chimeric antigen receptor T-cell therapy.
TL;DR: There were similar processes but different intensity of inflammatory responses of sCRS in COVID-19 and CAR-T group, and the diagnose and management of severe CO VID-19-related sC RS can learn lessons from treatment of s CRS induced byCAR-T therapy.
Posted ContentDOI
COVID-19 infection results in alterations of the kynurenine pathway and fatty acid metabolism that correlate with IL-6 levels and renal status
Tiffany Thomas,Davide Stefanoni,Julie A. Reisz,Travis Nemkov,Lorenzo Bertolone,Richard O. Francis,Krystalyn E. Hudson,James C. Zimring,Kirk C. Hansen,Eldad A. Hod,Steven L. Spitalnik,Angelo D'Alessandro +11 more
TL;DR: This initial observational study of the metabolic consequences of CO VID-19 infection in a clinical cohort identified amino acid metabolism (especially kynurenine and cysteine/taurine) and fatty acid metabolism as correlates of COVID-19, providing mechanistic insights, potential markers of clinical severity, and potential therapeutic targets.
References
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TL;DR: There is evidence that human-to-human transmission has occurred among close contacts since the middle of December 2019 and considerable efforts to reduce transmission will be required to control outbreaks if similar dynamics apply elsewhere.
Journal ArticleDOI
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
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