SARS-CoV-2: a storm is raging.
Savannah F. Pedersen,Ya Chi Ho +1 more
TLDR
Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design and the authors found that respiratory distress on admission is associated with unfavorable outcomes.Abstract:
The pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunological characteristics between moderate and severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10, and TNF-α), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFN-γ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design.read more
Citations
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Frailty Pathogenesis, Assessment, and Management in Older Adults With COVID-19
TL;DR: In this paper, the authors reviewed the progress of the research on the potential pathogenesis, evaluation methods and intervention measures of the elderly COVID-19 patients with frailty, which provides a reference for scientific and reasonable comprehensive diagnosis and treatment in clinical.
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Molecular characterization and amino acid homology of nucleocapsid (N) Protein in SARS-CoV-1, SARS-CoV-2, MERS-CoV, and bat coronavirus
TL;DR: The existing differences in nucleocapsid molecular structures in Sars-CoV-2 make this virus more virulent and highly infectious, which means that the non-identical SARS-Cov-2 genes are responsible for COVID-19 severity.
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COVID-19, internists and resilience: the north-south Italy outbreak.
TL;DR: Italy gained, at a world level, the highest number of total confirmed cases and deaths on April 1st 2020 and the distribution of infected subjects and deaths was not homogeneous, being respectively about 7‐times and 12‐times higher in northern‐ than in southern regions.
Journal ArticleDOI
Off-the-shelf CAR natural killer cells secreting IL-15 target spike in treating COVID-19
Ting-wei Lu,Ruiz Benito Ma,Wenjuan Dong,Kun-Yu Teng,Daniel S. Kollath,Zhi-Ying Li,Jinhee Yi,Christian Bustillos,Shoubao Ma,L. Tian,Anthony Mansour,Zhenlong Li,Erik W. Settles,Jianying Zhang,Paul Keim,Bridget M. Barker,Michael A. Caligiuri,Jianhua Yu +17 more
TL;DR: In this article , a chimeric antigen receptor (CAR) consisting of an extracellular domain of ACE2 was used to target the spike protein of SARS-CoV-2.
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Potential Use of Alpha-1 Anti-trypsin in the Covid-19 Treatment.
TL;DR: This approach may readily permit to identify and use safe drugs, until knowledge on the viral biology will allow to identify specific SARS-CoV-2 drugs and/or vaccines.
References
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Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia.
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TL;DR: There is evidence that human-to-human transmission has occurred among close contacts since the middle of December 2019 and considerable efforts to reduce transmission will be required to control outbreaks if similar dynamics apply elsewhere.
Journal ArticleDOI
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
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