SARS-CoV-2: a storm is raging.
Savannah F. Pedersen,Ya Chi Ho +1 more
TLDR
Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design and the authors found that respiratory distress on admission is associated with unfavorable outcomes.Abstract:
The pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunological characteristics between moderate and severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10, and TNF-α), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFN-γ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design.read more
Citations
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Pentoxifylline and Oxypurinol: Potential Drugs to Prevent the "Cytokine Release (Storm) Syndrome" Caused by SARS-CoV-2?
TL;DR: Pentoxifylline and oxypurinol are licensed drugs used for diseases other than COVID-19 and, therefore, phase I clinical trials would not be necessary for administration to SARS-CoV2- infected people, and it would be worth trying their potential effects against hyperinflammatory response to SARV2 infection.
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Ambient Temperature Stable, Scalable COVID-19 Polymer Particle Vaccines Induce Protective Immunity.
Shuxiong Chen,Benjamin Evert,Adetayo A. Adeniyi,Mercè Salla-Martret,Linda H.L. Lua,Victoria Ozberk,Manisha Pandey,Michael F. Good,Andreas Suhrbier,Peter Halfmann,Yoshihiro Kawaoka,Bernd H. A. Rehm +11 more
TL;DR: In this article, the authors used a biopolymer particle (BP) vaccine technology that can be quickly adapted to new and emerging variants of SARS-CoV-2 to combat the COVID-19 pandemic.
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Management strategies for patients with autoimmune diseases during the COVID-19 pandemic: A perspective from China.
TL;DR: Today is April 4th, the Chinese traditional “Tomb-Sweeping Day” when people mourn their dead, and the designated National Mourning Day to grieve over those who perished as a result of the COVID-19 pandemic.
Journal ArticleDOI
On the Origin of Neutrophil Extracellular Traps in COVID-19
TL;DR: In this paper , potential inducers of neutrophil extracellular traps (NETs) formation in severe COVID-19 and potential treatment options targeting NETs formation of removal are discussed.
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Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as markers for predicting the severity in covid-19 patients: A prospective observational study
Yudhyavir Singh,Abhishek Singh,Swetha Rudravaram,Kapil Dev Soni,Richa Aggarwal,Nishant Patel,Naveet Wig,Anjan Trikha +7 more
TL;DR: In this article, the role of neutrophil-to-lymphocyte ratio (NLR) and platelet-tolyphocyte (PLR) ratio has been investigated to predict disease progression.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia.
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TL;DR: There is evidence that human-to-human transmission has occurred among close contacts since the middle of December 2019 and considerable efforts to reduce transmission will be required to control outbreaks if similar dynamics apply elsewhere.
Journal ArticleDOI
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
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