SARS-CoV-2: a storm is raging.
Savannah F. Pedersen,Ya Chi Ho +1 more
TLDR
Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design and the authors found that respiratory distress on admission is associated with unfavorable outcomes.Abstract:
The pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunological characteristics between moderate and severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10, and TNF-α), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFN-γ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design.read more
Citations
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Asthma-associated risk for COVID-19 development.
TL;DR: The concept that patients suffering from different asthma endotypes present with a different risk profile in terms of SARS-CoV-2 infection, development of CO VID-19, and progression to severe COVID-19 outcomes is proposed.
Journal ArticleDOI
Addressing male sexual and reproductive health in the wake of COVID-19 outbreak.
Andrea Sansone,Daniele Mollaioli,Giacomo Ciocca,Erika Limoncin,Elena Colonnello,Walter Vena,Emmanuele A. Jannini +6 more
TL;DR: COVID-19 survivors might develop sexual and reproductive health issues and treatment with phosphodiesterase-5 (PDE5) inhibitors might be beneficial for both CO VID-19 and ED.
Journal ArticleDOI
Identifying potential anti-COVID-19 pharmacological components of traditional Chinese medicine Lianhuaqingwen capsule based on human exposure and ACE2 biochromatography screening.
Xiaofei Chen,Yun-Long Wu,Chun Chen,Yanqiu Gu,Chunyan Zhu,Suping Wang,Jiayun Chen,Lei Zhang,Lei Lv,Guoqing Zhang,Yongfang Yuan,Yifeng Chai,Mingshe Zhu,Caisheng Wu +13 more
TL;DR: Chemical and biochemical evidence is provided for exploring molecular mechanisms of therapeutic effects of LHQW capsule for the treatment of COVID-19 patients based on the components exposed to human and the utility of the human exposure-based approach to identify pharmaceutically active components in Chinese herb medicines is demonstrated.
Journal ArticleDOI
Neutrophilia and NETopathy as Key Pathologic Drivers of Progressive Lung Impairment in Patients With COVID-19
Teluguakula Narasaraju,Benjamin Tang,Martin Herrmann,Sylviane Muller,Vincent T. K. Chow,Marko Z. Radic +5 more
TL;DR: The need to develop therapies aimed at inhibiting neutrophil recruitment, activation, degranulation, and neutrophIL extracellular trap (NET) release is argued and currently available pharmacologic approaches should be tested as treatments for ARDS in COVID-19.
Journal ArticleDOI
Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology.
Deidiane Elisa Ribeiro,Ágatha Oliveira-Giacomelli,Talita Glaser,Vanessa Fernandes Arnaud-Sampaio,Roberta Andrejew,Luiz Henrique Junqueira Dieckmann,Juliana Baranova,Claudiana Lameu,Mariusz Z. Ratajczak,Henning Ulrich +9 more
TL;DR: Elevated levels of extracellular ATP induced by SARS-CoV-2 infection may trigger hyperactivation of P2X7 receptors leading to NLRP3 inflammasome stimulation as a key mediator of neuroinvasion and consequent neuroinflammatory processes, as observed in psychiatric disorders and neurodegenerative diseases.
References
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Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia.
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TL;DR: There is evidence that human-to-human transmission has occurred among close contacts since the middle of December 2019 and considerable efforts to reduce transmission will be required to control outbreaks if similar dynamics apply elsewhere.
Journal ArticleDOI
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
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